A1 Refereed original research article in a scientific journal

Zn2+ promoted hydrolysis of oligonucleotides



Authors: Kuusela S, Guzaev A, Lonnberg H

Publisher: INST ORGANIC CHEM AND BIOCHEM

Publication year: 1996

Journal: Collection of Czechoslovak Chemical Communications

Journal name in source: COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS

Journal acronym: COLLECT CZECH CHEM C

Volume: 61

First page : S30

Last page: S32

Number of pages: 3

ISSN: 0010-0765


Abstract

The Zn2+ promoted hydrolysis of short oligonucleotides has been studied. The results obtained show that thr presence of an adjacent phosphate group enhances the metal ion promoted hydrolysis of phosphodiester bonds. The effect of dianionic monophosphate groups is 10-fold larger than that of monoanionic phosphodiester bond. The mechanism of the rate-enhancement will be discussed.



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