A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä
Epithelial Integrins with Special Reference to Oral Epithelia
Tekijät: Larjava H, Koivisto L, Hakkinen L, Heino J
Kustantaja: SAGE PUBLICATIONS INC
Julkaisuvuosi: 2011
Journal: Journal of Dental Research
Tietokannassa oleva lehden nimi: JOURNAL OF DENTAL RESEARCH
Lehden akronyymi: J DENT RES
Numero sarjassa: 12
Vuosikerta: 90
Numero: 12
Aloitussivu: 1367
Lopetussivu: 1376
Sivujen määrä: 10
ISSN: 0022-0345
DOI: https://doi.org/10.1177/0022034511402207
Tiivistelmä
Adhesion of epithelium to the extracellular matrix is crucial for the maintenance of systemic and oral health. In the oral cavity, teeth or artificial dental implants penetrate the soft tissue of the gingiva. In this interface, gingival soft tissue needs to be well attached via the epithelial seal to the tooth or implant surface to maintain health. After injury or wounding, epithelial tissue rapidly migrates to form the initial epithelial cover to restore the barrier against infection. These events are crucially dependent on deposition of extracellular matrix and proper activation and function of integrin receptors in the epithelial cells. Recent experimental evidence suggests that epithelial integrins also participate in the regulation of periodontal inflammation. In this review, we will discuss the structure and function of epithelial integrins and their extracellular ligands and elaborate on their potential role in disease and repair processes in the oral cavity.
Adhesion of epithelium to the extracellular matrix is crucial for the maintenance of systemic and oral health. In the oral cavity, teeth or artificial dental implants penetrate the soft tissue of the gingiva. In this interface, gingival soft tissue needs to be well attached via the epithelial seal to the tooth or implant surface to maintain health. After injury or wounding, epithelial tissue rapidly migrates to form the initial epithelial cover to restore the barrier against infection. These events are crucially dependent on deposition of extracellular matrix and proper activation and function of integrin receptors in the epithelial cells. Recent experimental evidence suggests that epithelial integrins also participate in the regulation of periodontal inflammation. In this review, we will discuss the structure and function of epithelial integrins and their extracellular ligands and elaborate on their potential role in disease and repair processes in the oral cavity.
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