Involvement of histamine 1 receptor in seizure susceptibility and neuroprotection in immature mice

: Kukko-Lukjanov TK, Lintunen M, Jalava N, Lauren HB, Lopez-Picon FR, Michelsen KA, Panula P, Holopainen IE

Publisher: ELSEVIER SCIENCE BV

: 2010

: Epilepsy Research

: EPILEPSY RESEARCH

: EPILEPSY RES

: 1-2

: 90

: 1-2

: 8

: 15

: 8

: 0920-1211

DOI: https://doi.org/10.1016/j.eplepsyres.2010.02.012

In the H1 receptor KO mice, behavioral seizures were significantly more severe and duration of seizures was significantly longer when compared to the wild type (WT) mice at the KA dose of 2 mg/kg. Moreover, neuronal damage correlated with seizure severity, and it was significantly increased in the thalamus and retrosplenial granular cortex (RGC) of the KO mice. The H1 receptor antagonist triprolidine treatment supported these findings by showing significantly increased seizures severity and neuronal damage in the septum, thalamus, CA3 region of the hippocampus, and RGC in the KA-treated WT mice. Our present novel findings suggest that H1 receptors play a pivotal role in the regulation of seizure intensity and duration as well as seizure-induced neuronal damage in the immature P9 mice. (C) 2010 Elsevier B.V. All rights reserved.