A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Project DyAdd: Fatty acids and cognition in adults with dyslexia, ADHD, or both
Tekijät: Laasonen M, Hokkanen L, Leppamaki S, Tani P, Erkkila AT
Kustantaja: ELSEVIER SCI LTD
Julkaisuvuosi: 2009
Journal: Prostaglandins, Leukotrienes and Essential Fatty Acids
Tietokannassa oleva lehden nimi: PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
Lehden akronyymi: PROSTAG LEUKOTR ESS
Vuosikerta: 81
Numero: 1
Aloitussivu: 79
Lopetussivu: 88
Sivujen määrä: 10
ISSN: 0952-3278
DOI: https://doi.org/10.1016/j.plefa.2009.04.004
Tiivistelmä
Both attention deficit hyperactivity disorder (ADHD) and dyslexia are suggested to co-occur with altered fatty acid (FA) metabolism, but it is unknown how FAs are associated with the cognitive domains that characterize these disorders. In the project DyAdd, we investigated the associations between FAs in serum phospholipids and phonological processing, reading, spelling, arithmetic, executive functions, and attention. Healthy controls (n = 36), adults with ADHD (n = 26), dyslexia (n = 36), or both (n = 9) were included in the Study. FAs included saturated, monounsaturated, total polyunsaturated, n-3, and n-6 FAs, together with n-6/n-3, AA/EPA, and LA/ALA ratios. When all the study Subjects were included in the analyses, especially polyunsaturated FAs (PUFAs) were positively associated with cognition, but reading was least associated with FAs. These associations were modulated by gender, intelligence, n-3 PUFA intake, and group. Accordingly, within the ADHD group, only few associations emerged with PUFAs, n-6 PUFAs, and cognitive domains, whereas in the dyslexia group the more prevalent associations appeared with PUFAs and n-3 PUFAs. (C) 2009 Elsevier Ltd. All rights reserved
Both attention deficit hyperactivity disorder (ADHD) and dyslexia are suggested to co-occur with altered fatty acid (FA) metabolism, but it is unknown how FAs are associated with the cognitive domains that characterize these disorders. In the project DyAdd, we investigated the associations between FAs in serum phospholipids and phonological processing, reading, spelling, arithmetic, executive functions, and attention. Healthy controls (n = 36), adults with ADHD (n = 26), dyslexia (n = 36), or both (n = 9) were included in the Study. FAs included saturated, monounsaturated, total polyunsaturated, n-3, and n-6 FAs, together with n-6/n-3, AA/EPA, and LA/ALA ratios. When all the study Subjects were included in the analyses, especially polyunsaturated FAs (PUFAs) were positively associated with cognition, but reading was least associated with FAs. These associations were modulated by gender, intelligence, n-3 PUFA intake, and group. Accordingly, within the ADHD group, only few associations emerged with PUFAs, n-6 PUFAs, and cognitive domains, whereas in the dyslexia group the more prevalent associations appeared with PUFAs and n-3 PUFAs. (C) 2009 Elsevier Ltd. All rights reserved
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