Catalytic Decarboxylative Fluorination for the Synthesis of Tri- and Difluoromethyl Arenes



: Mizuta S, Stenhagen ISR, O'Duill M, Wolstenhulme J, Kirjavainen AK, Forsback SJ, Tredwell M, Sandford G, Moore PR, Huiban M, Luthra SK, Passchier J, Solin O, Gouverneur V

Publisher: AMER CHEMICAL SOC

: 2013

: Organic Letters

: ORGANIC LETTERS

: ORG LETT

: 11

: 15

: 11

: 2648

: 2651

: 4

: 1523-7060

DOI: https://doi.org/10.1021/ol4009377


Treatment of readily available alpha,alpha-difluoro- and alpha-fluoroarylacetic acids with Selecffluor under Ag(I) catalysis led to decarboxylative fluorination. This operationally simple reaction gave access to tri- and difluoromethylarenes applying a late-stage fluorination strategy. Translation to [F-18]labeling is demonstrated using [F-18]Selectfluor bis(triflate), a reagent affording [F-18]tri- and [F-18]difluoromethylarenes not within reach with [F-18]F-2.



Last updated on 2024-26-11 at 16:18