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Simultaneous quantitative analysis of Fc gamma RI (CD64) and CR1 (CD35) on neutrophils in distinguishing between bacterial infections, viral infections, and inflammatory diseases




TekijätJalava-Karvinen P, Hohenthal U, Laitinen I, Kotilainen P, Rajamaki A, Nikoskelainen J, Lilius EM, Nuutila J

KustantajaACADEMIC PRESS INC ELSEVIER SCIENCE

Julkaisuvuosi2009

JournalClinical Immunology

Tietokannassa oleva lehden nimiCLINICAL IMMUNOLOGY

Lehden akronyymiCLIN IMMUNOL

Vuosikerta133

Numero3

Aloitussivu314

Lopetussivu323

Sivujen määrä10

ISSN1521-6616

DOIhttps://doi.org/10.1016/j.clim.2009.08.003


Tiivistelmä
A flow cytometric quantitative analysis of receptors on neutrophils can be exploited in distinguishing between inflammatory and infectious diseases. In this prospective comparative study, simultaneous quantitative analysis of CD64 and CD35 on peripheral blood neutrophils was performed in febrile patients in order to differentiate between bacterial infections (n=89), viral infections (n=46), and inflammatory diseases (n=21). The patient data was compared to 60 healthy controls. We could divide patients into three groups depending on how they express CD35 and CD64 on neutrophils: (1) patients with a high probability of viral infection (tow CD35/low CD64 and low CD35/high CD64), (2) patients with a high probability of inflammatory disease (high CD35/low CD64), and (3) patients with a high probability of bacterial infection (high CD35/high CD64). In summary, simultaneous quantitative analysis of CD64 and CD35 on neutrophils could potentially assist physicians to distinguish between inflammatory and infectious diseases. (C) 2009 Elsevier Inc. All rights reserved.



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