A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Porous 3D modeled scaffolds of bioactive glass and photocrosslinkable poly(epsilon-caprolactone) by stereolithography
Tekijät: Elomaa L, Kokkari A, Narhi T, Seppala JV
Kustantaja: ELSEVIER SCI LTD
Julkaisuvuosi: 2013
Journal: Composites Science and Technology
Tietokannassa oleva lehden nimi: COMPOSITES SCIENCE AND TECHNOLOGY
Lehden akronyymi: COMPOS SCI TECHNOL
Vuosikerta: 74
Aloitussivu: 99
Lopetussivu: 106
Sivujen määrä: 8
ISSN: 0266-3538
DOI: https://doi.org/10.1016/j.compscitech.2012.10.014
Tiivistelmä
Bioactive glass is known to benefit cell interactions of polymeric tissue engineering scaffolds. Most likely, the best response is obtained when the glass is on the scaffold surface without a cover. We combined a photocrosslinkable poly(epsilon-caprolactone) resin with bioactive glass in a rapid prototyping process. Bioactive glass was homogeneously distributed through the highly porous scaffolds and their surface. Ion release measurements in simulated body fluid revealed a rapid decrease in calcium and phosphorus concentrations. The presence of calcium phosphate deposits on the surface of the composite scaffolds indicated in vitro bioactivity. The bioactive glass increased the metabolic activity of fibroblasts. Our work showed that stereolithography enables the fabrication of well-defined composite scaffolds in which the bioactive glass is homogeneously distributed on the surface and readily available for rapid ion release and cell interactions. By stereolithography, an unwanted polymer layer covering the BG particles on the scaffold surface can be successfully avoided. (c) 2012 Elsevier Ltd. All rights reserved.
Bioactive glass is known to benefit cell interactions of polymeric tissue engineering scaffolds. Most likely, the best response is obtained when the glass is on the scaffold surface without a cover. We combined a photocrosslinkable poly(epsilon-caprolactone) resin with bioactive glass in a rapid prototyping process. Bioactive glass was homogeneously distributed through the highly porous scaffolds and their surface. Ion release measurements in simulated body fluid revealed a rapid decrease in calcium and phosphorus concentrations. The presence of calcium phosphate deposits on the surface of the composite scaffolds indicated in vitro bioactivity. The bioactive glass increased the metabolic activity of fibroblasts. Our work showed that stereolithography enables the fabrication of well-defined composite scaffolds in which the bioactive glass is homogeneously distributed on the surface and readily available for rapid ion release and cell interactions. By stereolithography, an unwanted polymer layer covering the BG particles on the scaffold surface can be successfully avoided. (c) 2012 Elsevier Ltd. All rights reserved.
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