A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Total and Carboxylated Osteocalcin Associate with Insulin Levels in Young Adults Born with Normal or Very Low Birth Weight
Tekijät: Paldanius PM, Ivaska KK, Hovi P, Andersson S, Eriksson JG, Vaananen K, Kajantie E, Makitie O
Kustantaja: PUBLIC LIBRARY SCIENCE
Julkaisuvuosi: 2013
Journal: PLoS ONE
Tietokannassa oleva lehden nimi: PLOS ONE
Lehden akronyymi: PLOS ONE
Artikkelin numero: ARTN e63036
Numero sarjassa: 5
Vuosikerta: 8
Numero: 5
Sivujen määrä: 8
ISSN: 1932-6203
DOI: https://doi.org/10.1371/journal.pone.0063036
Tiivistelmä
OBJECTIVE: Osteocalcin (OC), a bone-derived protein, has been
implicated in the regulation of glucose and energy metabolism. Young adults
born with very low birth weight (VLBW) have altered glucose regulation and
lower bone mineral density (BMD) compared with those born at term. The aim of
this study was to explore the association between bone and glucose metabolism
in healthy young adults born prematurely or at term. METHODS: The cohort of
this cross-sectional study comprised 332 non-diabetic young adults (age 18 to
27 years) born either preterm with VLBW (n = 163) or at term (n = 169). OC,
carboxylated osteocalcin (cOC) and markers of glucose metabolism were measured at fasting and after a 75-g oral glucose tolerance test (OGTT). RESULTS: VLBW adults were shorter, had lower BMD (p<0.001) and higher fasting OC (p = 0.027) and cOC (p = 0.005) than term-born subjects. They also had higher 2-hour insulin (p = 0.001) and glucose (p = 0.037) concentrations. OGTT induced a significant reduction in OC (p<0.001), similar in both groups. OC reduction was not associated with OGTT-induced increases in insulin (p = 0.54). However, fasting total OC and cOC correlated negatively with fasting insulin after adjustment for age, gender, BMD and VLBW status (r = -0.182, p = 0.009 and r =-0.283, p<0.001, respectively). CONCLUSION: Adults born with VLBW have higher OC and cOC than their peers born at term. This may in part reflect the mechanisms that underlie their lower BMD and decreased insulin sensitivity.
Serum OC appears to be negatively associated with long-term glucose regulation
whereas acute changes during OGTT may be mediated via other mechanisms.
OBJECTIVE: Osteocalcin (OC), a bone-derived protein, has been
implicated in the regulation of glucose and energy metabolism. Young adults
born with very low birth weight (VLBW) have altered glucose regulation and
lower bone mineral density (BMD) compared with those born at term. The aim of
this study was to explore the association between bone and glucose metabolism
in healthy young adults born prematurely or at term. METHODS: The cohort of
this cross-sectional study comprised 332 non-diabetic young adults (age 18 to
27 years) born either preterm with VLBW (n = 163) or at term (n = 169). OC,
carboxylated osteocalcin (cOC) and markers of glucose metabolism were measured at fasting and after a 75-g oral glucose tolerance test (OGTT). RESULTS: VLBW adults were shorter, had lower BMD (p<0.001) and higher fasting OC (p = 0.027) and cOC (p = 0.005) than term-born subjects. They also had higher 2-hour insulin (p = 0.001) and glucose (p = 0.037) concentrations. OGTT induced a significant reduction in OC (p<0.001), similar in both groups. OC reduction was not associated with OGTT-induced increases in insulin (p = 0.54). However, fasting total OC and cOC correlated negatively with fasting insulin after adjustment for age, gender, BMD and VLBW status (r = -0.182, p = 0.009 and r =-0.283, p<0.001, respectively). CONCLUSION: Adults born with VLBW have higher OC and cOC than their peers born at term. This may in part reflect the mechanisms that underlie their lower BMD and decreased insulin sensitivity.
Serum OC appears to be negatively associated with long-term glucose regulation
whereas acute changes during OGTT may be mediated via other mechanisms.
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