A1 Refereed original research article in a scientific journal
Physical illnesses, developmental risk factors and psychiatric diagnoses among subjects at risk of psychosis
Authors: Korkeila J, Salokangas RKR, Heinimaa M, Svirskis T, Laine T, Ruhrmann S, Reventlow H von, Juckel G, Linszen D, Birchwood M, Klosterkötter J, the EPOS Group
Publication year: 2013
Journal: European Psychiatry
Number in series: 3
Volume: 28
Issue: 3
First page : 135
Last page: 140
Number of pages: 6
ISSN: 0924-9338
DOI: https://doi.org/10.1016/j.eurpsy.2011.06.005
Abstract
Background. - Subjects with psychoses have significantly increased rates of physical illnesses, but the nature of the relationship remains largely unknown.
Material and methods. - The present study is part of the European Prediction of Psychosis Study (EPOS). Data were collected from 245 help-seeking individuals from six European centers (age 16-35) who met criteria for ultra-high risk of psychosis criteria. This paper seeks to investigate self-reported physical ill health and its associations with psychiatric symptoms and disorders, risk factors, and onset of psychosis during 48 months of follow-up.
Results. - In multivariate analysis, lifetime panic disorder (OR = 2.43, 95% CI: 1.03-5.73), known complications during pregnancy and delivery (OR = 2.81, 95% CI: 1.10-7.15), female gender (OR = 2.88, 95% CI: 1.16-7.17), family history of psychosis (OR = 3.08, 95% CI: 1.18-8.07), and having a relationship (OR = 3.44, 95% CI: 1.33-8.94) were significantly associated with self-reported physician-diagnosed illness. In the Cox proportional hazard model we found no significant differences between those who had undergone a transition to psychosis and those who had not.
Conclusions. - The physical health of patients defined to be at ultra-high risk of psychosis seems to be commonly impaired and associated with female gender, marital status, complications during pregnancy and birth, lifetime panic disorder, and genetic risk of psychosis. (C) 2011 Elsevier Masson SAS. All rights reserved.
Background. - Subjects with psychoses have significantly increased rates of physical illnesses, but the nature of the relationship remains largely unknown.
Material and methods. - The present study is part of the European Prediction of Psychosis Study (EPOS). Data were collected from 245 help-seeking individuals from six European centers (age 16-35) who met criteria for ultra-high risk of psychosis criteria. This paper seeks to investigate self-reported physical ill health and its associations with psychiatric symptoms and disorders, risk factors, and onset of psychosis during 48 months of follow-up.
Results. - In multivariate analysis, lifetime panic disorder (OR = 2.43, 95% CI: 1.03-5.73), known complications during pregnancy and delivery (OR = 2.81, 95% CI: 1.10-7.15), female gender (OR = 2.88, 95% CI: 1.16-7.17), family history of psychosis (OR = 3.08, 95% CI: 1.18-8.07), and having a relationship (OR = 3.44, 95% CI: 1.33-8.94) were significantly associated with self-reported physician-diagnosed illness. In the Cox proportional hazard model we found no significant differences between those who had undergone a transition to psychosis and those who had not.
Conclusions. - The physical health of patients defined to be at ultra-high risk of psychosis seems to be commonly impaired and associated with female gender, marital status, complications during pregnancy and birth, lifetime panic disorder, and genetic risk of psychosis. (C) 2011 Elsevier Masson SAS. All rights reserved.
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