A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
The effects of height and BMI on prostate cancer incidence and mortality: a Mendelian randomization study in 20,848 cases and 20,214 controls from the PRACTICAL consortium
Tekijät: Davies NM, Gaunt TR, Lewis SJ, Holly J, Donovan JL, Hamdy FC, Kemp JP, Eeles R, Easton D, Kote-Jarai Z, Al Olama AA, Benlloch S, Muir K, Giles GG, Wiklund F, Gronberg H, Haiman CA, Schleutker J, Nordestgaard BG, Travis RC, Neal D, Pashayan N, Khaw KT, Stanford JL, Blot WJ, Thibodeau S, Maier C, Kibel AS, Cybulski C, Cannon-Albright L, Brenner H, Park J, Kaneva R, Batra J, Teixeira MR, Pandha H, Lathrop M, Smith GD, Martin RM
Kustantaja: SPRINGER
Julkaisuvuosi: 2015
Journal: Cancer Causes and Control
Tietokannassa oleva lehden nimi: CANCER CAUSES & CONTROL
Lehden akronyymi: CANCER CAUSE CONTROL
Vuosikerta: 26
Numero: 11
Aloitussivu: 1603
Lopetussivu: 1616
Sivujen määrä: 14
ISSN: 0957-5243
DOI: https://doi.org/10.1007/s10552-015-0654-9
Conclusions We found little evidence of a substantial effect of genetically elevated height or BMI on prostate cancer risk, suggesting that previously reported observational associations may reflect common environmental determinants of height or BMI and prostate cancer risk. Genetically elevated height and BMI were associated with increased mortality (prostate cancer-specific and all-cause, respectively) in men with low-grade disease, a potentially informative but novel finding that requires replication.
