A1 Refereed original research article in a scientific journal

ABC-cassette transporter 1 (ABCA1) expression in epithelial cells in Chlamydia pneumoniae infection



Authors: Korhonen JT, Olkkonen VM, Lahesmaa R, Puolakkainen M

Publisher: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD

Publishing place: LONDON; 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND

Publication year: 2013

Journal: Microbial Pathogenesis

Journal name in source: Microbial pathogenesis

Journal acronym: Microb.Pathog.

Volume: 61-62

First page : 57

Last page: 61

Number of pages: 5

ISSN: 0882-4010

DOI: https://doi.org/10.1016/j.micpath.2013.05.006(external)


Abstract
ATP-binding cassette transporter A1 (ABCA1) mediates reverse cholesterol transport and innate immunity response in different cell types. We have investigated the regulation of ABCA1 expression in response to intracellular Chlamydia pneumoniae infection in A549 epithelial lung carcinoma cells. C. pneumoniae infection decreased ABCA1 expression in A549 cells, and the activity of the ABCA1 promoter was decreased. The decreased promoter activity was dependent on its E-box and GnT-box elements of the promoter. Chlamydial growth was decreased in ABCA1-silenced epithelial lung carcinoma cells. These data indicate an important role for ABCA1 in intracellular bacterial infection. (c) 2013 Elsevier Ltd. All rights reserved.



Last updated on 2024-26-11 at 22:13