A2 Refereed review article in a scientific journal
Metal-related oxidative stress in birds
Authors: Koivula MJ, Eeva T
Publisher: ELSEVIER SCI LTD
Publication year: 2010
Journal: Environmental Pollution
Journal name in source: ENVIRONMENTAL POLLUTION
Journal acronym: ENVIRON POLLUT
Number in series: 7
Volume: 158
Issue: 7
First page : 2359
Last page: 2370
Number of pages: 12
ISSN: 0269-7491
DOI: https://doi.org/10.1016/j.envpol.2010.03.013
Abstract
Metals can cause oxidative stress by increasing the formation of reactive oxygen species (ROS), which render antioxidants incapable of defence against growing amounts of free radicals. Metal toxicity is related to their oxidative state and reactivity with other compounds. Our aim is to review the mechanisms on how metals cause oxidative stress and what is known about metal-induced oxidative stress in wildlife. Taking birds as model organisms, we summarize the mechanisms responsible for antioxidant depletion and give a view of how to detect metal-induced oxidative stress in birds by using different biomarkers. The mechanisms producing the harmful effects of oxidative stress are complex with different biomolecular mechanisms associated with ecotoxicological and ecological aspects. The majority of the studies concerning metals and ROS related to oxidative stress have focused on the biomolecular level, but little is known about the effects at the cellular level or at the level of individuals or populations. (C) 2010 Elsevier Ltd. All rights reserved.
Metals can cause oxidative stress by increasing the formation of reactive oxygen species (ROS), which render antioxidants incapable of defence against growing amounts of free radicals. Metal toxicity is related to their oxidative state and reactivity with other compounds. Our aim is to review the mechanisms on how metals cause oxidative stress and what is known about metal-induced oxidative stress in wildlife. Taking birds as model organisms, we summarize the mechanisms responsible for antioxidant depletion and give a view of how to detect metal-induced oxidative stress in birds by using different biomarkers. The mechanisms producing the harmful effects of oxidative stress are complex with different biomolecular mechanisms associated with ecotoxicological and ecological aspects. The majority of the studies concerning metals and ROS related to oxidative stress have focused on the biomolecular level, but little is known about the effects at the cellular level or at the level of individuals or populations. (C) 2010 Elsevier Ltd. All rights reserved.
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