A1 Refereed original research article in a scientific journal

Brain derived neurotrophic factor induces a rapid upregulation of synaptophysin and tau proteins via the neurotrophin receptor TrkB in rat cerebellar granule cells




AuthorsCoffey ET, Akerman KEO, Courtney MJ

PublisherELSEVIER SCI IRELAND LTD

Publication year1997

JournalNeuroscience Letters

Journal name in sourceNEUROSCIENCE LETTERS

Journal acronymNEUROSCI LETT

Volume227

Issue3

First page 177

Last page180

Number of pages4

ISSN0304-3940

DOIhttps://doi.org/10.1016/S0304-3940(97)00335-2(external)


Abstract
We have examined the effects of neurotrophins brain derived neurotrophic factor (BDNF) and nerve growth factor (NGF) on the expression of the maturation-specific proteins synaptophysin end tau, and the growth-associated protein (GAP)-43 in cerebellar granule cells. We find that BDNF but not NGF rapidly (within 2 h) upregulates levels of synaptophysin, tau and c-Fos correlating with expression of the neurotrophin receptor TrkB. The rapid increase in synaptophysin is not preceded by c-Fos elevation suggesting a post-transcriptional mechanism may be involved. In contrast, no upregulation of GAP-43 levels are seen within this time period. Phorbol ester mimics the effects of BDNF, indicating that protein kinase C (PKC) is either a component of, or feeds into the signalling mechanism. We conclude that BDNF, characterized to be survival promoting early in differentiation of cerebellar granule cells, enhances maturation at a later stage. (C) 1997 Elsevier Science Ireland Ltd.



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