A1 Refereed original research article in a scientific journal
Comparative metagenomics of microbial traits within oceanic viral communities
Authors: Sharon I, Battchikova N, Aro EM, Giglione C, Meinnel T, Glaser F, Pinter RY, Breitbart M, Rohwer F, Beja O
Publisher: NATURE PUBLISHING GROUP NATURE PUBLISHING GROUP
Publication year: 2011
Journal: ISME Journal
Journal name in source: ISME JOURNAL
Journal acronym: ISME J
Number in series: 7
Volume: 5
Issue: 7
First page : 1178
Last page: 1190
Number of pages: 13
ISSN: 1751-7362
DOI: https://doi.org/10.1038/ismej.2011.2(external)
Abstract
Viral genomes often contain genes recently acquired from microbes. In some cases (for example, psbA) the proteins encoded by these genes have been shown to be important for viral replication. In this study, using a unique search strategy on the Global Ocean Survey (GOS) metagenomes in combination with marine virome and microbiome pyrosequencing-based datasets, we characterize previously undetected microbial metabolic capabilities concealed within the genomes of uncultured marine viral communities. A total of 34 microbial gene families were detected on 452 viral GOS scaffolds. The majority of auxiliary metabolic genes found on these scaffolds have never been reported in phages. Host genes detected in viruses were mainly divided between genes encoding for different energy metabolism pathways, such as electron transport and newly identified photosystem genes, or translation and post-translation mechanism related. Our findings suggest previously undetected ways, in which marine phages adapt to their hosts and improve their fitness, including translation and post-translation level control over the host rather than the already known transcription level control. The ISME Journal (2011) 5, 1178-1190; doi:10.1038/ismej.2011.2; published online 10 February 2011 Subject Category: integrated genomics and post-genomics approaches in microbial ecology
Viral genomes often contain genes recently acquired from microbes. In some cases (for example, psbA) the proteins encoded by these genes have been shown to be important for viral replication. In this study, using a unique search strategy on the Global Ocean Survey (GOS) metagenomes in combination with marine virome and microbiome pyrosequencing-based datasets, we characterize previously undetected microbial metabolic capabilities concealed within the genomes of uncultured marine viral communities. A total of 34 microbial gene families were detected on 452 viral GOS scaffolds. The majority of auxiliary metabolic genes found on these scaffolds have never been reported in phages. Host genes detected in viruses were mainly divided between genes encoding for different energy metabolism pathways, such as electron transport and newly identified photosystem genes, or translation and post-translation mechanism related. Our findings suggest previously undetected ways, in which marine phages adapt to their hosts and improve their fitness, including translation and post-translation level control over the host rather than the already known transcription level control. The ISME Journal (2011) 5, 1178-1190; doi:10.1038/ismej.2011.2; published online 10 February 2011 Subject Category: integrated genomics and post-genomics approaches in microbial ecology
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