A1 Journal article – refereed

Autosomal Dominant Diabetes Arising From a Wolfram Syndrome 1 Mutation




List of Authors: Bonnycastle LL, Chines PS, Hara T, Huyghe JR, Swift AJ, Heikinheimo P, Mahadevan J, Peltonen S, Huopio H, Nuutila P, Narisu N, Goldfeder RL, Stitzel ML, Lu SM, Boehnke M, Urano F, Collins FS, Laakso M

Publisher: AMER DIABETES ASSOC

Publication year: 2013

Journal: Diabetes

Journal name in source: DIABETES

Journal acronym: DIABETES

Number in series: 11

Volume number: 62

Issue number: 11

Number of pages: 8

ISSN: 0012-1797

DOI: http://dx.doi.org/10.2337/db13-0571


Abstract
We used an unbiased genome-wide approach to identify exonic variants segregating with diabetes in a multigenerational Finnish family. At least eight members of this family presented with diabetes with age of diagnosis ranging from 18 to 51 years and a pattern suggesting autosomal dominant inheritance. We sequenced the exomes of four affected members of this family and performed follow-up genotyping of additional affected and unaffected family members. We uncovered a novel nonsynonymous variant (p.Trp314Arg) in the Wolfram syndrome 1 (WFS1) gene that segregates completely with the diabetic phenotype. Multipoint parametric linkage analysis with 13 members of this family identified a single linkage signal with maximum logarithm of odds score 3.01 at 4p16.2-p16.1, corresponding to a region harboring the WFS1 locus. Functional studies demonstrate a role for this variant in endoplasmic reticulum stress, which is consistent with the -cell failure phenotype seen in mutation carriers. This represents the first compelling report of a mutation in WFS1 associated with dominantly inherited nonsyndromic adult-onset diabetes.


Last updated on 2021-24-06 at 11:19