A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Twenty-eight genetic loci associated with ST-T-wave amplitudes of the electrocardiogram
Tekijät: Verweij N, Mateo Leach I, Isaacs A, Arking DE, Bis JC, Pers TH, Van Den Berg ME, Lyytikäinen LP, Barnett P, Wang X; LifeLines Cohort Study., Soliman EZ, Van Duijn CM, Kähönen M, Van Veldhuisen DJ, Kors JA, Raitakari OT, Silva CT, Lehtimäki T, Hillege HL, Hirschhorn JN, Boyer LA, Van Gilst WH, Alonso A, Sotoodehnia N, Eijgelsheim M, De Boer RA, De Bakker PI, Franke L, Van Der Harst P
Julkaisuvuosi: 2016
Journal: Human Molecular Genetics
Vuosikerta: 25
Numero: 10
Aloitussivu: 2093
Lopetussivu: 2103
Sivujen määrä: 11
ISSN: 0964-6906
DOI: https://doi.org/10.1093/hmg/ddw058
The ST-segment and adjacent T-wave (ST-T wave) amplitudes of the electrocardiogram are quantitative characteristics of cardiac repolarization. Repolarization abnormalities have been linked to ventricular arrhythmias and sudden cardiac death. We performed the first genome-wide association meta-analysis of ST-T-wave amplitudes in up to 37 977 individuals identifying 71 robust genotype–phenotype associations clustered within 28 independent loci. Fifty-four genes were prioritized as candidates underlying the phenotypes, including genes with established roles in the cardiac repolarization phase (SCN5A/SCN10A, KCND3, KCNB1, NOS1AP and HEY2) and others with as yet undefined cardiac function. These associations may provide insights in the spatiotemporal contribution of genetic variation influencing cardiac repolarization and provide novel leads for future functional follow-up.