This chapter focuses on design thinking and innovations in healthcare from the ethical perspective. The ethical perspective concerns the good and bad, right and wrong, and what are the values, principles, and goals behind human behavior or conducting of actions. The aim of ethical reflection in this chapter is to provide insights for carrying out design thinking in ethically best possible ways as well as for making ethically justifiable innovations. In addition, ethical reflection in design thinking will support researchers or developers to identify unethical or harmful practices or decisions during the innovation process. Thus, it is important to include ethical reflection on all stages of design process. In this chapter, the design thinking process from empathizing to ideate, prototype, and test (Marcus et al., J Med Ethics 46(4):282–284, 2020), will be first reflected in relation to empathy, what is widely reflected concept of ethics. As design thinking aims to produce new ideas, products, or practices, it is meaningful to consider how it relates to medicalization but also sustainability. At the end, design thinking will be considered as a research or development process and research ethics will be reflected.