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Genome-wide Association Study Identifies 27 Loci Influencing Concentrations of Circulating Cytokines and Growth Factors
Tekijät: Ahola-Olli AV, Wurtz P, Havulinna AS, Aalto K, Pitkanen N, Lehtimaki T, Kahonen M, Lyytikainen LP, Raitoharju E, Seppala I, Sarin AP, Ripatti S, Palotie A, Perola M, Viikari JS, Jalkanen S, Maksimow M, Salomaa V, Salmi M, Kettunen J, Raitakari OT
Kustantaja: American Society of Human Genetics. Published by Elsevier Inc
Kustannuspaikka: United States
Julkaisuvuosi: 2017
Journal: American Journal of Human Genetics
Tietokannassa oleva lehden nimi: American Journal of Human Genetics
Lehden akronyymi: Am.J.Hum.Genet.
Vuosikerta: 100
Numero: 1
Aloitussivu: 40
Lopetussivu: 50
Sivujen määrä: 11
ISSN: 0002-9297
DOI: https://doi.org/10.1016/j.ajhg.2016.11.007
Circulating cytokines and growth factors are regulators of inflammation and have been implicated in autoimmune and metabolic diseases. In this genome-wide association study (GWAS) of up to 8,293 Finns we identified 27 genome-widely significant loci (p < 1.2 x 10-9) for one or more cytokines. Fifteen of the associated variants had expression quantitative trait loci in whole blood. We provide genetic instruments to clarify the causal roles of cytokine signaling and upstream inflammation in immune-related and other chronic diseases. We further link inflammatory markers with variants previously associated with autoimmune diseases such as Crohn disease, multiple sclerosis, and ulcerative colitis and hereby elucidate the molecular mechanisms underpinning these diseases and suggest potential drug targets.
