Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1)
Cold-stimulated brown adipose tissue activation is related to changes in serum metabolites relevant to NAD+ metabolism in humans
Julkaisun tekijät: U-Din Mueez, de Mello Vanessa D, Tuomainen Marjo, Raiko Juho, Niemi Tarja, Fromme Tobias, Klåvus Anton, Gautier Nadine, Haimilahti Kimmo, Lehtonen Marko, Kristiansen Karsten, Newman John W, Pietiläinen Kirsi H, Pihlajamäki Jussi, Amri Ez-Zoubir, Klingenspor Martin, Nuutila Pirjo, Pirinen Eija, Hanhineva Kati, Virtanen Kirsi A
Kustantaja: Cell Press
Julkaisuvuosi: 2023
Journal: Cell Reports
Tietokannassa oleva lehden nimi: Cell reports
Lehden akronyymi: Cell Rep
Artikkelin numero: 113131
Volyymi: 42
Julkaisunumero: 9
eISSN: 2211-1247
DOI: http://dx.doi.org/10.1016/j.celrep.2023.113131
Verkko-osoite: https://doi.org/10.1016/j.celrep.2023.113131
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/181156630
Cold-induced brown adipose tissue (BAT) activation is considered to improve metabolic health. In murine BAT, cold increases the fundamental molecule for mitochondrial function, nicotinamide adenine dinucleotide (NAD+), but limited knowledge of NAD+ metabolism during cold in human BAT metabolism exists. We show that cold increases the serum metabolites of the NAD+ salvage pathway (nicotinamide and 1-methylnicotinamide) in humans. Additionally, individuals with cold-stimulated BAT activation have decreased levels of metabolites from the de novo NAD+ biosynthesis pathway (tryptophan, kynurenine). Serum nicotinamide correlates positively with cold-stimulated BAT activation, whereas tryptophan and kynurenine correlate negatively. Furthermore, the expression of genes involved in NAD+ biosynthesis in BAT is related to markers of metabolic health. Our data indicate that cold increases serum tryptophan conversion to nicotinamide to be further utilized by BAT. We conclude that NAD+ metabolism is activated upon cold in humans and is probably regulated in a coordinated fashion by several tissues.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
