A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä

Metformin versus insulin for gestational diabetes: Adiposity variables and adipocytokines in offspring at age of 9 years




TekijätPaavilainen Elisa, Niinikoski Harri, Parkkola Riitta, Koskensalo Kalle, Nikkinen Hilkka, Veijola Riitta, Vääräsmäki Marja, Loo Britt-Marie, Tossavainen Päivi, Rönnemaa Tapani, Tertti Kristiina

KustantajaELSEVIER IRELAND LTD

Julkaisuvuosi2023

JournalDiabetes Research and Clinical Practice

Tietokannassa oleva lehden nimiDIABETES RESEARCH AND CLINICAL PRACTICE

Lehden akronyymiDIABETES RES CLIN PR

Artikkelin numero 110780

Vuosikerta202

Sivujen määrä8

ISSN0168-8227

eISSN1872-8227

DOIhttps://doi.org/10.1016/j.diabres.2023.110780

Verkko-osoitehttps://www.sciencedirect.com/science/article/pii/S0168822723005430?via%3Dihub

Rinnakkaistallenteen osoitehttps://research.utu.fi/converis/portal/detail/Publication/180475222


Tiivistelmä

Aims

To compare body composition, visceral adiposity, adipocytokines, and low-grade inflammation markers in prepubertal offspring of mothers who were treated with metformin or insulin for gestational diabetes mellitus (GDM).

Methods

172 offspring of 311 mothers randomized to receive metformin (n = 82) or insulin (n = 90) for GDM were studied at 9 years of age (follow-up rate 55%). Measurements included anthropometrics, adipocytokines, markers of the low-grade inflammation, abdominal magnetic resonance imaging (MRI), magnetic liver spectrometry (MRS), and whole body dual-energy X-ray absorptiometry (DXA).

Results

Serum markers of low-grade inflammation, visceral adipose tissue volume, total fat percentage, and liver fat percentage were similar between the study groups. Serum adiponectin concentration was higher in children in the metformin group compared to insulin group (median 10.37 vs 9.50 & μg/ml, p = 0.016). This difference between groups was observed in boys only (median 12.13 vs 7.50 & μg/ml, p < 0.001). Leptin/adiponectin-ratio was lower in boys in the metformin group than in the insulin group (median 0.30 vs 0.75; p = 0.016).

Conclusions

Maternal metformin treatment for GDM had no effects on adiposity, body composition, liver fat, or inflammation markers in prepubertal offspring compared to maternal insulin treatment but was associated with higher adiponectin concentration and lower leptin/adiponectin-ratio in boys.


Ladattava julkaisu

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Last updated on 2024-26-11 at 10:59