A1 Journal article – refereed

Admission sodium level and prognosis in adult Guillain-Barré syndrome




List of Authors: Sipilä JO, Kauko T, Soilu-Hänninen M.

Publisher: Taylor & Francis

Publication year: 2017

Journal: International Journal of Neuroscience

Volume number: 127

Issue number: 4

Number of pages: 4

ISSN: 0020-7454

DOI: http://dx.doi.org/10.3109/00207454.2016.1163551


Abstract
PURPOSE:

Guillain-Barré
syndrome (GBS) varies in severity and outcome. Hyponatremia predicts
poor outcome but previous studies have used divergent methodology and
(pseudo)hyponatremia caused by intravenous immunoglobulin administration
may confound analysis. We studied if the plasma sodium level at
admission was associated with GBS outcome.

METHODS:

All
69 patients at least 16 years of age treated for GBS in Turku
University Hospital in 2004-2013 were included in the study. Clinical
information was obtained from patient charts.

RESULTS:

Women
had lower sodium levels at admission (138; IQR 135, 140) compared to
men (140; IQR 138, 142; p = 0.0116) but no association of sodium levels
with demographics, pre-hospital variables or basic GBS characteristics
was found. Multivariate analyses showed lower admission sodium levels to
be associated with worse functional status at one year from disease
onset (OR 1.37; 95% CI 1.07-1.76; p = 0.0136) and probability of being
discharged to another care facility from the hospital (OR 1.31; 95% CI
1.05-1.64; p = 0.0180) but not associated with need of intensive care
unit care (p = 0.09) or mechanical ventilation (p = 0.45), length of
hospital stay (p =0.48) or functional status at six months (p = 0.07).

CONCLUSIONS:

Low
plasma sodium level at admission is associated with a more severe
disease course and a worse outcome in GBS independently of previously
identified prognostic factors. Hyponatremia does not, however, appear to
be caused by disease-specific factors.


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Last updated on 2021-24-06 at 09:57