Refereed review article in scientific journal (A2)
Brown Adipose Tissue: Activation and Metabolism in Humans
List of Authors: Hachemi Imane, U-Din Mueez
Publisher: KOREAN ENDOCRINE SOC
Publication year: 2023
Journal: Endocrinology and metabolism
Journal name in source: ENDOCRINOLOGY AND METABOLISM
Journal acronym: ENDOCRINOL METAB
Volume number: 38
Issue number: 2
Start page: 214
End page: 222
Number of pages: 9
ISSN: 2093-596X
eISSN: 2093-5978
DOI: http://dx.doi.org/10.3803/EnM.2023.1659
URL: https://doi.org/10.3803/EnM.2023.1659
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/179843717
Brown adipose tissue (BAT) is a thermogenic organ contributing to non-shivering thermogenesis. BAT becomes active under cold stress via sympathetic nervous system activation. However, recent evidence has suggested that BAT may also be active at thermo-neutrality and in a postprandial state. BAT has superior energy dissipation capacity compared to white adipose tissue (WAT) and muscles. Thus, it has been proposed that the recruitment and activation of additional BAT may increase the overall energy-expending capacity in humans, potentially improving current whole-body weight management strategies. Nutrition plays a central role in obesi-ty and weight management. Thus, this review discusses human studies describing BAT hyper-metabolism after dietary interventions. Nutritional agents that can potentially recruit brown adipocytes via the process of BAT-WAT transdifferentiation are also discussed.
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