Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1)
Effect of immunization during pregnancy and pre-existing immunity on diphtheria-tetanus-acellular pertussis vaccine responses in infants
Julkaisun tekijät: Knuutila Aapo, Barkoff Alex Mikael, Ivaska Lauri, Tenhu Elina, Teräsjärvi Johanna, van Gageldonk Pieter, Buisman Annemarie, Mertsola Jussi, He Qiushui; and PERISCOPE consortium
Kustantaja: TAYLOR & FRANCIS LTD
Julkaisuvuosi: 2023
Journal: Emerging microbes & infections
Tietokannassa oleva lehden nimi: EMERGING MICROBES & INFECTIONS
Lehden akronyymi: EMERG MICROBES INFEC
Artikkelin numero: 2204146
Volyymi: 12
Julkaisunumero: 1
Sivujen määrä: 11
DOI: http://dx.doi.org/10.1080/22221751.2023.2204146
Verkko-osoite: https://doi.org/10.1080/22221751.2023.2204146
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/179733733
Immunization during pregnancy (IP) against pertussis is recommended in many countries to protect infants. Although maternal antibodies can influence the infants' antibody responses to primary vaccinations, their effect on the development of functional antibodies and B cells remain poorly studied. We investigated the maternal immune response to IP and the effect of IP and pre-existing antibodies on infants' primary vaccine responses in an open-label, non-randomized trial. Forty-seven mothers received tetanus-diphtheria-acellular pertussis (Tdap) vaccine during pregnancy, and 22 mothers were included as controls. Sixty-nine infants received primary doses of DTaP at three and five months of age. Geometric mean concentrations of antibodies to pertussis toxin, filamentous haemagglutinin, pertactin, diphtheria, and tetanus toxins, pertussis toxin neutralizing antibodies (PTNAs), and plasma and memory B-cell frequencies were studied at delivery, and at three, five and six months. Levels of antibodies, PTNAs, and frequencies of memory B-cells were significantly increased at delivery and up to six months after in mothers with IP compared to those without IP (all p < 0.05, except for PT-specific memory B-cells). In vaccinated pregnant women, high pre-existing antibody levels were positively correlated with higher antibody responses after IP. IP blunted the infants' antibody and plasma B-cell responses to all vaccine antigens, except for tetanus toxin. This blunting effect was the strongest in infants with high concentrations of maternal antibodies. In conclusion, IP resulted in significantly higher concentrations of antibodies in infants up to three months of age (all p < 0.05); but was associated with blunting of various infants' vaccine responses.
Ladattava julkaisu This is an electronic reprint of the original article. |  |
