A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Childhood Socioeconomic Status in Predicting Metabolic Syndrome and Glucose Abnormalities in Adulthood: The Cardiovascular Risk in Young Finns Study
Tekijät: Puolakka E, Pahkala K, Laitinen TT, Magnussen CG, Hutri-Kahonen N, Tossavainen P, Jokinen E, Sabin MA, Laitinen T, Elovainio M, Pulkki-Raback L, Viikari JSA, Raitakari OT, Juonala M
Kustantaja: AMER DIABETES ASSOC
Julkaisuvuosi: 2016
Journal: Diabetes Care
Tietokannassa oleva lehden nimi: DIABETES CARE
Lehden akronyymi: DIABETES CARE
Vuosikerta: 39
Numero: 12
Aloitussivu: 2311
Lopetussivu: 2317
Sivujen määrä: 7
ISSN: 0149-5992
DOI: https://doi.org/10.2337/dc16-1565
Tiivistelmä
OBJECTIVEWe prospectively examined whether family socioeconomic status (SES) in childhood is associated with metabolic syndrome (MetS), impaired fasting glucose (IFG), or type 2 diabetes in adulthood.RESEARCH DESIGN AND METHODSThe sample comprised 2,250 participants from the longitudinal Cardiovascular Risk in Young Finns Study cohort. Participants were 3-18 years old at baseline (mean age 10.6 years), and they were followed for 31 years. SES was characterized as reported annual income of the family and classified on an 8-point scale.RESULTSFor each 1-unit increase in family SES in childhood, the risk for adult MetS decreased (risk ratio [95% confidence interval] 0.94 [0.90-0.98]; P = 0.003) when adjusted for age, sex, childhood cardiometabolic risk factors (lipids, systolic blood pressure, insulin, and BMI), childhood physical activity, and fruit and vegetable consumption. The association remained after adjustment for participants' own SES in adulthood (0.95 [0.91-0.99]; P = 0.005). A similar association was seen between childhood SES and the risk of having either adult IFG or type 2 diabetes (0.96 [0.92-0.99]; P = 0.01, age and sex adjusted). This association became nonsignificant after adjustment for childhood risk factors (P = 0.08). Of the individual components of MetS, lower SES in childhood predicted large waist circumference (0.96 [0.93-0.99]; P = 0.003) and a high triglycerides concentration (0.96 [0.92-1.00]; P = 0.04) after adjustment for the aforementioned risk factors.CONCLUSIONSLower SES in childhood may be associated with an increased risk for MetS, IFG, and type 2 diabetes in adulthood. Special attention could be paid to children of low SES families to decrease the prevalence of MetS in adulthood.
OBJECTIVEWe prospectively examined whether family socioeconomic status (SES) in childhood is associated with metabolic syndrome (MetS), impaired fasting glucose (IFG), or type 2 diabetes in adulthood.RESEARCH DESIGN AND METHODSThe sample comprised 2,250 participants from the longitudinal Cardiovascular Risk in Young Finns Study cohort. Participants were 3-18 years old at baseline (mean age 10.6 years), and they were followed for 31 years. SES was characterized as reported annual income of the family and classified on an 8-point scale.RESULTSFor each 1-unit increase in family SES in childhood, the risk for adult MetS decreased (risk ratio [95% confidence interval] 0.94 [0.90-0.98]; P = 0.003) when adjusted for age, sex, childhood cardiometabolic risk factors (lipids, systolic blood pressure, insulin, and BMI), childhood physical activity, and fruit and vegetable consumption. The association remained after adjustment for participants' own SES in adulthood (0.95 [0.91-0.99]; P = 0.005). A similar association was seen between childhood SES and the risk of having either adult IFG or type 2 diabetes (0.96 [0.92-0.99]; P = 0.01, age and sex adjusted). This association became nonsignificant after adjustment for childhood risk factors (P = 0.08). Of the individual components of MetS, lower SES in childhood predicted large waist circumference (0.96 [0.93-0.99]; P = 0.003) and a high triglycerides concentration (0.96 [0.92-1.00]; P = 0.04) after adjustment for the aforementioned risk factors.CONCLUSIONSLower SES in childhood may be associated with an increased risk for MetS, IFG, and type 2 diabetes in adulthood. Special attention could be paid to children of low SES families to decrease the prevalence of MetS in adulthood.
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