A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Computed tomography versus invasive coronary angiography: design and methods of the pragmatic randomised multicentre DISCHARGE trial
Tekijät: Napp AE, Haase R, Laule M, Schuetz GM, Rief M, Dreger H, Feuchtner G, Friedrich G, Špaček M, Suchánek V, Fuglsang Kofoed K, Engstroem T, Schroeder S, Drosch T, Gutberlet M, Woinke M, Maurovich-Horvat P1, Merkely B, Donnelly P, Ball P, Dodd JD, Quinn M, Saba L, Porcu M, Francone M, Mancone M, Erglis A, Zvaigzne L, Jankauskas A, Sakalyte G, Harań T, Ilnicka-Suckiel M, Bettencourt N, Gama-Ribeiro V, Condrea S, Benedek I, Čemerlić Adjić N, Adjić O, Rodriguez-Palomares J, Garcia Del Blanco B, Roditi G, Berry C, Davis G, Thwaite E, Knuuti J, Pietilä M, Kępka C, Kruk M, Vidakovic R, Neskovic AN, Díez I, Lecumberri I, Geleijns J, Kubiak C, Strenge-Hesse A, Do TH, Frömel F, Gutiérrez-Ibarluzea I, Benguria-Arrate G, Keiding H, Katzer C, Müller-Nordhorn J, Rieckmann N, Walther M, Schlattmann P, Dewey M; DISCHARGE Trial Group.
Kustantaja: SPRINGER
Julkaisuvuosi: 2017
Journal: European Radiology
Tietokannassa oleva lehden nimi: EUROPEAN RADIOLOGY
Lehden akronyymi: EUR RADIOL
Vuosikerta: 27
Numero: 7
Aloitussivu: 2957
Lopetussivu: 2968
Sivujen määrä: 12
ISSN: 0938-7994
eISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-016-4620-z
Objectives
More than 3.5 million invasive coronary angiographies (ICA) are performed in Europe annually. Approximately 2 million of these invasive procedures might be reduced by noninvasive tests because no coronary intervention is performed. Computed tomography (CT) is the most accurate noninvasive test for detection and exclusion of coronary artery disease (CAD). To investigate the comparative effectiveness of CT and ICA, we designed the European pragmatic multicentre DISCHARGE trial funded by the 7th Framework Programme of the European Union (EC-GA 603266).
MethodsIn this trial, patients with a low-to-intermediate pretest probability (10–60 %) of suspected CAD and a clinical indication for ICA because of stable chest pain will be randomised in a 1-to-1 ratio to CT or ICA. CT and ICA findings guide subsequent management decisions by the local heart teams according to current evidence and European guidelines.
ResultsMajor adverse cardiovascular events (MACE) defined as cardiovascular death, myocardial infarction and stroke as a composite endpoint will be the primary outcome measure. Secondary and other outcomes include cost-effectiveness, radiation exposure, health-related quality of life (HRQoL), socioeconomic status, lifestyle, adverse events related to CT/ICA, and gender differences.
ConclusionsThe DISCHARGE trial will assess the comparative effectiveness of CT and ICA.
