A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Current understanding of fear learning and memory in humans and animal models and the value of a linguistic approach for analyzing fear learning and memory in humans
Tekijät: Raber J, Arzy S, Boulanger-Bertolus J, Depue B, Haas HE, Hofmann SG, Kangas M, Kensinger E, Lowry CA, Marusak HA, Minnier J, Mouly AM, Muhlberger A, Norrholm SD, Peltonen K, Pinna G, Rabinak C, Shiban Y, Soreq H, van der Kooij MA, Lower L, Weingast LT, Yamashita P, Boutros SW
Kustantaja: PERGAMON-ELSEVIER SCIENCE LTD
Julkaisuvuosi: 2019
Journal: Neuroscience and Biobehavioral Reviews
Tietokannassa oleva lehden nimi: NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
Lehden akronyymi: NEUROSCI BIOBEHAV R
Vuosikerta: 105
Aloitussivu: 136
Lopetussivu: 177
Sivujen määrä: 42
ISSN: 0149-7634
DOI: https://doi.org/10.1016/j.neubiorev.2019.03.015
Fear is an emotion that serves as a driving factor in how organisms move through the world. In this review, we discuss the current understandings of the subjective experience of fear and the related biological processes involved in fear learning and memory. We first provide an overview of fear learning and memory in humans and animal models, encompassing the neurocircuitry and molecular mechanisms, the influence of genetic and environmental factors, and how fear learning paradigms have contributed to treatments for fear-related disorders, such as posttraumatic stress disorder. Current treatments as well as novel strategies, such as targeting the perisynaptic environment and use of virtual reality, are addressed. We review research on the subjective experience of fear and the role of autobiographical memory in fear-related disorders. We also discuss the gaps in our understanding of fear learning and memory, and the degree of consensus in the field. Lastly, the development of linguistic tools for assessments and treatment of fear learning and memory disorders is discussed.
