Refereed journal article or data article (A1)
Cord serum metabolic signatures of future progression to immune-mediated diseases
List of Authors: Hyötyläinen Tuulia, Karthikeyan Bagavathy S., Ghaffarzadegan Tannaz, Triplett Eric W., Orešič Matej, Ludvigsson Johnny
Publisher: Elsevier Inc.
Publication year: 2023
Journal: iScience
Journal name in source: iScience
Volume number: 26
Issue number: 3
ISSN: 2589-0042
eISSN: 2589-0042
DOI: http://dx.doi.org/10.1016/j.isci.2023.106268
URL: https://www.sciencedirect.com/science/article/pii/S2589004223003450?via%3Dihub
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/179267340
Previous prospective studies suggest that progression to autoimmune diseases is preceded by metabolic dysregulation, but it is not clear which metabolic changes are disease-specific and which are common across multiple immune-mediated diseases. Here we investigated metabolic profiles in cord serum in a general population cohort (All Babies In Southeast Sweden; ABIS), comprising infants who progressed to one or more immune-mediated diseases later in life: type 1 diabetes (n = 12), celiac disease (n = 28), juvenile idiopathic arthritis (n = 9), inflammatory bowel disease (n = 7), and hypothyroidism (n = 6); and matched controls (n = 270). We observed elevated levels of multiple triacylglycerols (TGs) an alteration in several gut microbiota related metabolites in the autoimmune groups. The most distinct differences were observed in those infants who later developed HT. The specific similarities observed in metabolic profiles across autoimmune diseases suggest that they share specific common metabolic phenotypes at birth that contrast with those of healthy controls.
Downloadable publication This is an electronic reprint of the original article. |