Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1)

Polygenic risk for neuroticism is associated with externalizing symptoms in 2-year-old boys




Julkaisun tekijätLiuhanen Johanna, Kantojärvi Katri, Acosta Henriette, Pietikäinen Johanna T., Nolvi Saara, Savukoski Minna, Kylliäinen Anneli, Pölkki Pirjo, Karlsson Hasse, Karlsson Linnea, Paavonen E. Juulia, Paunio Tiina

KustantajaElsevier Inc.

Julkaisuvuosi2023

JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry

Tietokannassa oleva lehden nimiProgress in Neuro-Psychopharmacology and Biological Psychiatry

Artikkelin numero110720

Volyymi123

eISSN1878-4216

DOIhttp://dx.doi.org/10.1016/j.pnpbp.2023.110720

Verkko-osoitehttps://doi.org/10.1016/j.pnpbp.2023.110720

Rinnakkaistallenteen osoitehttps://research.utu.fi/converis/portal/detail/Publication/178883696


Tiivistelmä

Recent advances in genome-wide association studies have enabled the estimation of genetic risk of complex traits, including neuroticism, with polygenic risk scores (PRS). Neuroticism PRS has been associated with psychiatric disorders and symptoms in adults, but studies in children are scarce. We studied whether neuroticism PRS, and its subscales, worry PRS and depressive affect PRS, were associated with externalizing and internalizing symptoms in 2-year-olds. We also examined parental neuroticism PRSs' association with children's externalizing and internalizing symptoms and whether parental depressive symptoms mediated the effect. Participants from two Finnish birth cohorts, CHILD-SLEEP and FinnBrain Birth Cohort Study, who had DNA and data on Brief Infant-Toddler Social and Emotional Assessment (BITSEA) available were included in the study (N = 806 and N = 987, respectively). PRSs were calculated based on GWAS data from UK Biobank. Child's neuroticism PRS, and its subscale worry PRS, were positively associated with externalizing symptoms in 2-year-old boys, but not in girls. Mother's depressive symptoms mediated the association between maternal neuroticism PRS and externalizing and internalizing symptoms in boys, but not in girls. Our results suggest that neuroticism PRS, and its subscale worry PRS, are associated with externalizing symptoms in already as young as 2-year-old boys, and, that subclinical symptoms of maternal depression that are based on genetic disposition, have an effect on boy's internalizing and externalizing symptoms. As we did not find any associations in girls, our study supports the suggestion that girls and boys may differ in how genetic and environmental factors contribute to their development.


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Last updated on 2023-24-11 at 13:46