A1 Refereed original research article in a scientific journal

Effect of mid-luteal phase GnRH agonist on frozen-thawed embryo transfers during natural menstrual cycles: a randomised clinical pilot study




AuthorsJaana Seikkula, Leena Anttila, Päivi Polo-Kantola, Risto Bloigu, Janne Engblom, Helena Tinkanen, Varpu Jokimaa

PublisherTaylor & Francis

Publication year2016

JournalGynecological Endocrinology

Journal name in sourceGynecological Endocrinology

Volume32

Issue12

First page 961

Last page964

Number of pages4

ISSN0951-3590

eISSN1473-0766

DOIhttps://doi.org/10.1080/09513590.2016.1196176


Abstract

This prospective randomised crossover study evaluated the effect of mid-luteal single-dose gonadotropin-releasing hormone agonist (triptoreline) on pregnancy outcomes in natural-cycle frozen embryo transfers (FETs). Ninety-eight women were randomised to receive either standard luteal support with vaginal micronised progesterone or an additional single dose of 0.1 mg triptoreline at the time of implantation. The intervention group was composed of 65 FET cycles and the control group of 62 cycles. In the intervention group, there were more positive pregnancy tests, clinical pregnancies and live births, but the differences did not reach statistical significance. The mean beta human chorionic gonadotropin (β-hCG) concentration of singleton pregnancies was significantly lower in the intervention group compared to the control group (p = 0.048). No difference was detected in the median birth weight of the newborns.



Last updated on 2024-26-11 at 14:25