This chapter shows selected practical cases studies dealing with advancing CR deployment. Section 6.1 provides details about TV White Space spectrum estimation methodology based on ITU GE06 Plan rules for cases of countries where high levels of TV interference exist. In addition, an example of addressing the practical co-existence of TV white space devices with incumbent applications in the UHF TV band is presented in this section as well. Section 6.2 looks at the practical possibilities of deploying CR systems in the ISM bands, including a techno-economic viability study of CR solutions in factory scenario. Finally, section 6.3 describes a concept and provides an in depth analysis of using CR technologies in medical environments.