Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1)
Smoking cessation and obesity-related morbidities and mortality in a 20-year follow-up study
Julkaisun tekijät: Suutari-Jääskö Asla, Ylitalo Antti, Ronkaine Justiina, Huikuri Heikki, Kesäniemi Antero Y., Ukkola Olavi H.
Kustantaja: Plos
Julkaisuvuosi: 2022
Journal: PLoS ONE
Artikkelin numero: e0279443
Volyymi: 17
Julkaisunumero: 12
DOI: http://dx.doi.org/10.1371/journal.pone.0279443
Verkko-osoite: https://doi.org/10.1371/journal.pone.0279443
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/178234558
Background: Smoking is the biggest preventable factor causing mortality and morbidity and the health benefits of smoking cessation are commonly known. Smoking cessation-related weight gain is well documented. We evaluated the association between smoking cessation and the incidence of obesity-related morbidities such as hypertension, diabetes and metabolic syndrome as well as mortality. We also evaluated telomere length related to smoking cessation.
Material and methods: This study was part of the OPERA (Oulu Project Elucidating Risk of Atherosclerosis) study. The mean follow up time among the 600 study subjects was 20 years. We divided the study subjects into four groups by smoking status ("never", "current", "ex-smokers" and "quit") and analyzed their health status. "Ex-smokers" had quit smoking before baseline and "quit" quit during the follow-up time. Information about total mortality between the years 2013-2020 was also utilized.
Results: During the follow-up time systolic blood pressure decreased the most in the "current" and in the "ex-smoker" groups. Office SBP decreased the least in the "quit" group (p = 0.001). BMI increased the most in the "quit" and the least in the "ex-smokers" group (p = 0.001). No significant increases were seen in the incidence of obesity-related-diseases, such as metabolic syndrome, hypertension and diabetes was seen. There was no significant difference in the shortening of telomeres. Odds of short-term mortality was increased in the "current" group (2.43 (CI 95% 1.10; 5.39)), but not in the "quit" (1.43 (CI 95% 0.73-2.80)) or "ex-smoker" (1.02 (CI 95% 0.56-1.86)) groups when compared to "never" group.
Conclusions: Even though, the blood pressure levels were unfavorable in the "quit" group, there was no significant increase in the incidence of obesity-related-diseases, and a noticeable benefit in short-term mortality was seen during the 6-year follow-up. The benefits of smoking cessation outweigh the disadvantages in the long-term.
Ladattava julkaisu This is an electronic reprint of the original article. |