Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1)
Peripheral Blood T-lymphocyte Phenotypes in Mother-Child Pairs Stratified by the Maternal HPV Status: Persistent HPV16 vs. HPV-Negative: A Case-Control Study
Julkaisun tekijät: Suominen Helmi, Paaso Anna, Koskimaa Hanna-Mari, Grénman Seija, Syrjänen Kari, Syrjänen Stina, Louvanto Karoliina
Kustantaja: MDPI
Paikka: Basel
Julkaisuvuosi: 2022
Journal: Viruses
Tietokannassa oleva lehden nimi: Viruses
Volyymi: 14
Julkaisunumero: 12
ISSN: 1999-4915
DOI: http://dx.doi.org/10.3390/v14122633
Verkko-osoite: https://doi.org/10.3390/v14122633
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/178117384
Only few studies exist on the phenotype distribution of peripheral blood lymphocytes concerning persistent oral HPV infection. T-lymphocyte subsets were phenotyped in women who had persistent genital or oral HPV16 infection, using HPV-negative women as a reference group. A subset of 42 mothers and their children (n = 28), were stratified into two groups according to the mothers' HPV status. PBMCs from previously cryopreserved venous samples were immunophenotyped by flow cytometry. Proportions of the CD4+ or CD8+ lymphocytes by their immunophenotype subsets were compared between HPV-positive and -negative mothers and their children. The mean rank distribution of CD8+ memory cells was significantly higher among mothers with persistent genital HPV16 infection. The median levels of both the antigen-presenting CD4+ cells and activated CD8+ cells were significantly lower in mothers with persistent oral HPV16 infection. When oral and genital HPV16-persistors were analyzed as a group, a marker of terminal effector cells was significantly increased as compared to HPV-negative women. Significantly higher levels of activated CD4+, CD8+ and circulating CD8+ memory cells were found among children whose mothers had persistent oral HPV16 infection. Persistent HPV16 infections are associated with changes in peripheral blood T-lymphocyte subsets. The mother's persistent oral HPV16 infection possibly results in immune alterations in her offspring.
Ladattava julkaisu This is an electronic reprint of the original article. |