Refereed journal article or data article (A1)
A large-scale genomic snapshot of Klebsiella spp. isolates in Northern Italy reveals limited transmission between clinical and non-clinical settings
List of Authors: Thorpe Harry A., Booton Ross, Kallonen Teemu, Gibbon Marjorie J., Couto Natacha, Passet Virginie, Loez-Fernadez Sebastian, Rodrigues Carla, Matthews Louise, Mitchell Sonia, Reeve Richard, David Sophia, Merla Cristina, Corbella Marta, Ferrari Carolina, Comandatore Francesco, Marone Piero, Brisse Sylvain, Sassera Davide, Corander Jukka, Feil Edward J.
Publisher: NATURE PORTFOLIO
Publication year: 2022
Journal: Nature Microbiology
Journal name in source: NATURE MICROBIOLOGY
Journal acronym: NAT MICROBIOL
Volume number: 7
Issue number: 12
Start page: 2054
End page: 2067
Number of pages: 24
ISSN: 2058-5276
eISSN: 2058-5276
DOI: http://dx.doi.org/10.1038/s41564-022-01263-0
URL: https://www.nature.com/articles/s41564-022-01263-0
Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/178027957
The Klebsiella group, found in humans, livestock, plants, soil, water and wild animals, is genetically and ecologically diverse. Many species are opportunistic pathogens and can harbour diverse classes of antimicrobial resistance genes. Healthcare-associated Klebsiella pneumoniae clones that are non-susceptible to carbapenems can spread rapidly, representing a high public health burden. Here we report an analysis of 3,482 genome sequences representing 15 Klebsiella species sampled over a 17-month period from a wide range of clinical, community, animal and environmental settings in and around the Italian city of Pavia. Northern Italy is a hotspot for hospital-acquired carbapenem non-susceptible Klebsiella and thus a pertinent setting to examine the overlap between isolates in clinical and non-clinical settings. We found no genotypic or phenotypic evidence for non-susceptibility to carbapenems outside the clinical environment. Although we noted occasional transmission between clinical and non-clinical settings, our data point to a limited role of animal and environmental reservoirs in the human acquisition of Klebsiella spp. We also provide a detailed genus-wide view of genomic diversity and population structure, including the identification of new groups.
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