A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä

A method to sequence and quantify DNA integration for monitoring outcome in gene therapy




TekijätBrady T, Roth SL, Malani N, Wang GP, Berry CC, Leboulch P, Hacein-Bey-Abina S, Cavazzana-Calvo M, Papapetrou EP, Sadelain M, Savilahti H, Bushman FD

KustantajaOXFORD UNIV PRESS

Julkaisuvuosi2011

JournalNucleic Acids Research

Tietokannassa oleva lehden nimiNUCLEIC ACIDS RESEARCH

Lehden akronyymiNUCLEIC ACIDS RES

Artikkelin numeroARTN e72

Numero sarjassa11

Vuosikerta39

Numero11

Sivujen määrä8

ISSN0305-1048

DOIhttps://doi.org/10.1093/nar/gkr140


Tiivistelmä

Human genetic diseases have been successfully corrected by integration of functional copies of the defective genes into human cells, but in some cases integration of therapeutic vectors has activated proto-oncogenes and contributed to leukemia. For this reason, extensive efforts have focused on analyzing integration site populations from patient samples, but the most commonly used methods for recovering newly integrated DNA suffer from severe recovery biases. Here, we show that a new method based on phage Mu transposition in vitro allows convenient and consistent recovery of integration site sequences in a form that can be analyzed directly using DNA barcoding and pyrosequencing. The method also allows simple estimation of the relative abundance of gene-modified cells from human gene therapy subjects, which has previously been lacking but is crucial for detecting expansion of cell clones that may be a prelude to adverse events.



Last updated on 2024-26-11 at 13:01