Vertaisarvioitu katsausartikkeli tieteellisessä aikakauslehdessä (A2)

Lymph node lymphatic endothelial cells as multifaceted gatekeepers in the immune system




Julkaisun tekijätTakeda Akira, Salmi Marko, Jalkanen Sirpa

KustantajaElsevier

Julkaisuvuosi2023

JournalTrends in Immunology

Tietokannassa oleva lehden nimiTrends in immunology

Lehden akronyymiTrends Immunol

Volyymi44

Julkaisunumero1

Aloitussivu72

Lopetussivun numero86

ISSN1471-4906

eISSN1471-4981

DOIhttp://dx.doi.org/10.1016/j.it.2022.10.010

Verkko-osoitehttps://doi.org/10.1016/j.it.2022.10.010

Rinnakkaistallenteen osoitehttps://research.utu.fi/converis/portal/detail/Publication/177784017


Tiivistelmä
Single-cell technologies have recently allowed the identification of multiple lymphatic endothelial cell (LEC) subsets in subcapsular, paracortical, medullary, and other lymph node (LN) sinus systems in mice and humans. New analyses show that LECs serve key immunological functions in the LN stroma during immune responses. We discuss the roles of different LEC types in guiding leukocyte and cancer cell trafficking to and from the LN parenchyma, in capturing microbes, and in transporting, presenting, and storing lymph-borne antigens in distinct types of lymphatic sinuses. We underscore specific adaptations of human LECs and raise unanswered questions concerning LEC functions in human disease. Despite our limited understanding of human lymphatics - hampering clinical translation in inflammation and metastasis - we support the potential of LN LECs as putative targets for boosting/inhibiting immunoreactivity.

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Last updated on 2023-12-01 at 13:54