Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1)

Mapping neurotransmitter systems to the structural and functional organization of the human neocortex

Julkaisun tekijät: Hansen Justine Y., Shafiei Golia, Markello Ross D., Smart Kelly, Cox Sylvia M. L., Nørgaard Martin, Beliveau Vincent, Wu Yanjun, Gallezot Jean-Dominique, Aumont Étienne, Servaes Stijn, Scala Stephanie G., DuBois Jonathan M., Wainstein Gabriel, Bezgin Gleb, Funck Thomas, Schmitz Taylor W., Spreng R. Nathan, Galovic Marian, Koepp Matthias J., Duncan John S., Coles Jonathan P., Fryer Tim D., Aigbirhio Franklin I., McGinnity Colm J., Hammers Alexander, Soucy Jean-Paul, Baillet Sylvain, Guimond Synthia, Hietala Jarmo, Bedard Marc-André, Leyton Marco, Kobayashi Eliane, Rosa-Neto Pedro, Ganz Melanie, Knudsen Gitte M., Palomero-Gallagher Nicola, Shine James M., Carson Richard E., Tuominen Lauri, Dagher Alain, Misic Bratislav


Julkaisuvuosi: 2022

Journal: Nature Neuroscience

Tietokannassa oleva lehden nimi: NATURE NEUROSCIENCE

Lehden akronyymi: NAT NEUROSCI

Volyymi: 25

Julkaisunumero: 11

Sivujen määrä: 18

ISSN: 1097-6256

eISSN: 1546-1726



Rinnakkaistallenteen osoite:


Neurotransmitter receptors support the propagation of signals in the human brain. How receptor systems are situated within macro-scale neuroanatomy and how they shape emergent function remain poorly understood, and there exists no comprehensive atlas of receptors. Here we collate positron emission tomography data from more than 1,200 healthy individuals to construct a whole-brain three-dimensional normative atlas of 19 receptors and transporters across nine different neurotransmitter systems. We found that receptor profiles align with structural connectivity and mediate function, including neurophysiological oscillatory dynamics and resting-state hemodynamic functional connectivity. Using the Neurosynth cognitive atlas, we uncovered a topographic gradient of overlapping receptor distributions that separates extrinsic and intrinsic psychological processes. Finally, we found both expected and novel associations between receptor distributions and cortical abnormality patterns across 13 disorders. We replicated all findings in an independently collected autoradiography dataset. This work demonstrates how chemoarchitecture shapes brain structure and function, providing a new direction for studying multi-scale brain organization.

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Last updated on 2022-29-11 at 15:11