Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1)

Detection of group A streptococcus in children with confirmed viral pharyngitis and antiviral host response




Julkaisun tekijät: Ivaska Lauri, Niemelä Jussi, Gröndahl-Yli-Hannuksela Kirsi, Putkuri Niina, Vuopio Jaana, Vuorinen Tytti, Waris Matti, Rantakokko-Jalava Kaisu, Peltola Ville

Kustantaja: Springer

Julkaisuvuosi: 2022

Journal: European Journal of Pediatrics

Tietokannassa oleva lehden nimi: EUROPEAN JOURNAL OF PEDIATRICS

Lehden akronyymi: EUR J PEDIATR

Volyymi: 181

Sivujen määrä: 7

ISSN: 0340-6199

eISSN: 1432-1076

DOI: http://dx.doi.org/10.1007/s00431-022-04633-2

Verkko-osoite: https://doi.org/10.1007/s00431-022-04633-2

Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/176749780


Tiivistelmä

Our aim was to study the detection of group A streptococcus (GAS) with different diagnostic methods in paediatric pharyngitis patients with and without a confirmed viral infection. In this prospective observational study, throat swabs and blood samples were collected from children (age 1-16 years) presenting to the emergency department with febrile pharyngitis. A confirmed viral infection was defined as a positive virus diagnostic test (nucleic acid amplification test [NAAT] and/or serology) together with an antiviral immune response of the host demonstrated by elevated (>= 175 mu g/L) myxovirus resistance protein A (MxA) blood concentration. Testing for GAS was performed by a throat culture, by 2 rapid antigen detection tests (StrepTop and mariPOC) and by 2 NAATs (Simplexa and Illumigene). Altogether, 83 children were recruited of whom 48 had samples available for GAS testing. Confirmed viral infection was diagnosed in 30/48 (63%) children with febrile pharyngitis. Enteroviruses 11/30 (37%), adenoviruses 9/30 (30%) and rhinoviruses 9/30 (30%) were the most common viruses detected. GAS was detected by throat culture in 5/30 (17%) with and in 6/18 (33%) patients without a confirmed viral infection. Respectively, GAS was detected in 4/30 (13%) and 6/18 (33%) by StrepTop, 13/30 (43%) and 10/18 (56%) by mariPOC, 6/30 (20%) and 9/18 (50%) by Simplexa, and 5/30 (17%) and 6/18 (30%) patients by Illumigene.

Conclusion: GAS was frequently detected also in paediatric pharyngitis patients with a confirmed viral infection. The presence of antiviral host response and increased GAS detection by sensitive methods suggest incidental throat carriage of GAS in viral pharyngitis.


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Last updated on 2023-20-01 at 11:26