Refereed journal article or data article (A1)

A pH-Responsive Cluster Metal-Organic Framework Nanoparticle for Enhanced Tumor Accumulation and Antitumor Effect

List of Authors: Cheng Ruoyu, Jiang Lingxi, Gao Han, Liu Zehua, Mäkilä Ermei, Wang Shiqi, Saiding Qimanguli, Xiang Lei, Tang Xiaomei, Shi Minmin, Liu Jia, Pang Libin, Salonen Jarno, Hirvonen Jouni, Zhang Hongbo, Cui Wenguo, Shen Baiyong, Santos Hélder A.


Publication year: 2022

Journal: Advanced Materials

Journal name in source: ADVANCED MATERIALS

Journal acronym: ADV MATER

Number of pages: 13

ISSN: 0935-9648

eISSN: 1521-4095



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As a result of the deficient tumor-specific antigens, potential off-target effect, and influence of protein corona, metal–organic framework nanoparticles have inadequate accumulation in tumor tissues, limiting their therapeutic effects. In this work, a pH-responsive linker (L) is prepared by covalently modifying oleylamine (OA) with 3-(bromomethyl)-4-methyl-2,5-furandione (MMfu) and poly(ethylene glycol) (PEG). Then, the L is embedded into a solid lipid nanoshell to coat apilimod (Ap)-loaded zeolitic imidazolate framework (Ap-ZIF) to form Ap-ZIF@SLN#L. Under the tumor microenvironment, the hydrophilic PEG and MMfu are removed, exposing the hydrophobic OA on Ap-ZIF@SLN#L, increasing their uptake in cancer cells and accumulation in the tumor. The ZIF@SLN#L nanoparticle induces reactive oxygen species (ROS). Ap released from Ap-ZIF@SLN#L significantly promotes intracellular ROS and lactate dehydrogenase generation. Ap-ZIF@SLN#L inhibits tumor growth, increases the survival rate in mice, activates the tumor microenvironment, and improves the infiltration of macrophages and T cells in the tumor, as demonstrated in two different tumor-bearing mice after injections with Ap-ZIF@SLN#TL. Furthermore, mice show normal tissue structure of the main organs and the normal serum level in alanine aminotransferase and aspartate aminotransferase after treatment with the nanoparticles. Overall, this pH-responsive targeting strategy improves nanoparticle accumulation in tumors with enhanced therapeutic effects.

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Last updated on 2022-03-10 at 12:20