Refereed journal article or data article (A1)

Physical exertion as a risk factor for perimesencephalic nonaneurysmal subarachnoid hemorrhage




List of Authors: Laukka Dan, Kivelev Juri, Rautio Riitta, Kuhmonen Johanna, Sinisalo Matias, Rinne Jaakko, Rahi Melissa

Publisher: Brain and Behavior

Publication year: 2022

Journal: Brain and Behavior

Journal acronym: Brain Behav.

Volume number: 12

Issue number: 9

DOI: http://dx.doi.org/10.1002/brb3.2756

Self-archived copy’s web address: https://research.utu.fi/converis/portal/detail/Publication/176242046


Abstract

Background: Perimesencephalic and nonperimesencephalic nonaneurysmal subarachnoid hemorrhage (PM-naSAH and NPM-naSAH) have a different bleeding pattern and clinical course. The etiology and risk factors for PM-naSAH and NPM-naSAH are unclear. The objective of this study was to compare risk factors and triggering events between PM-naSAH and NPM-naSAH.

Methods: We reviewed retrospectively all patients (n = 3475) who had undergone cerebral digital subtraction angiography between 2003 and 2020 at our tertiary hospital. Of these, 119 patients had 6-vessel angiography negative subarachnoid hemorrhage (47 (39%) PM-naSAH and 72 (61%) NPM-naSAH) and accurate information about the triggering event was available in 42 (89%) PM-NASAH and 64 (89%) NPM-naSAH patients.

Results: PM-naSAH were younger compared to NPM-naSAH (mean age [SD]; 55.3 [11.1] years vs. 59.6 [12.2] years, p = .045. PM-naSAH was triggered during the physical exertion in 79% of patients and 16% of patients with NPM-naSAH (relative risk 5.4; 95% CI, 2.9-10.1, p < .0001). There were no significant difference in sex, smoking, alcohol abuse, hypertension, diabetes, hyperlipidemia, or anticoagulation/antithrombotic usage between PM-naSAH and NMP-naSAH, p > .05.

Conclusion: Physical exertion was a triggering factor in most of the PM-naSAH cases and the risk was five times greater than in NMP-naSAH. More studies are needed to confirm our results and to study pathophysiology of PM-naSAH and NPM-naSAH.


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Last updated on 2022-26-09 at 14:40