Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1)
Breast Milk Lipidome Is Associated With Maternal Diet and Infants' Growth
Julkaisun tekijät: Calvo-Lerma Joaquim, Selma-Royo Marta, Hervas David, Yang Baoru, Intonen Linda, González Sonia, Martínez-Costa Cecilia, Linderborg Kaisa M, Collado Maria Carmen
Kustantaja: FRONTIERS MEDIA SA
Julkaisuvuosi: 2022
Journal: Frontiers in Nutrition
Tietokannassa oleva lehden nimi: FRONTIERS IN NUTRITION
Lehden akronyymi: FRONT NUTR
Artikkelin numero: 854786
Volyymi: 9
Sivujen määrä: 10
ISSN: 2296-861X
DOI: http://dx.doi.org/10.3389/fnut.2022.854786
Verkko-osoite: https://www.frontiersin.org/articles/10.3389/fnut.2022.854786/full
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/175969446
Objectives: The fatty acid (FA) composition of breast milk is a relevant aspect related to the development of the lactating infant. The present study aimed at exploring correlations between dietary intake of macro- and micronutrients with the FA profile in breast milk, and the possible implication for infants' growth.
Study Design: Breast milk samples from a cohort of lactating women were collected 7-15 days postpartum. The FA profiles in triacylglycerol (TAG) and phospholipid (PL)rich fractions were analyzed by gas chromatography. Diet was registered during the third trimester of pregnancy by means of a food frequency questionnaire (FFQ). In addition, anthropometric measurements of infants were collected from gestation and up to 12 months postpartum.
Results: The FA profile in breast milk was characterized by a median of 37.4, 41.3 and 16.8% of saturated, monounsaturated, and polyunsaturated FAs, respectively. From the dietary components, zinc, iron, and B group vitamins were correlated positively with the proportion of total n-3 FAs in TAG and C20:5 n-3 in PL. Lycopene, vitamin E, zinc, and vitamin B2 showed a similar correlation with total polyunsaturated fatty acid (PUFA), total n-6 FAs, C20:4 n-6, and C18:2 n-6 in TAG. Regarding food groups, nuts showed the strongest association with several PUFA both in TAG and PL, while the vegetable group was also positively associated with C18:3 n-3. Furthermore, the concentration of linolenic acid (C18:3 n-3) and palmitic acid (C16:0) were positively associated with increased length for age (LFA) and weight for age (WFA) at 12 months compared with birth [ALFA -0.16 (-0.85, 0.37); AWFA -0.26 (-0.77, 0.21)].
Conclusions: Mothers' intake of nuts, dietary sources of zinc, iron, and B group vitamins were identified as potential predictors of a high-unsaturated FA profile in breast milk. In addition, linolenic and palmitic acids in breast milk were positively associated with infants' growth in the first year of life.
Ladattava julkaisu This is an electronic reprint of the original article. |