Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1)

Prognostic value of left atrial volume index in degenerative mitral stenosis

Julkaisun tekijät: Yedidya Idit, Butcher Steele C, Stassen Jan, van der Bijl Pieter, Ngiam Jinghao Nicholas, Chew Nicholas WS, Sia Ching-Hui, Leow Ryan, Li Tony Yi-Wei, Kong William KF, Poh Kian Keong, Kornowski Ran, Marsan Nina Ajmone, Delgado Victoria, Bax Jeroen J

Kustantaja: SPRINGER

Julkaisuvuosi: 2022

Journal: International Journal of Cardiovascular Imaging


Lehden akronyymi: INT J CARDIOVAS IMAG

Sivujen määrä: 7

ISSN: 1569-5794

eISSN: 1573-0743



Rinnakkaistallenteen osoite:



Degenerative mitral stenosis (DMS) is associated with a poor prognosis. Although mean transmitral gradient (TMG) has shown a good correlation with outcome, little is known about the association between other echocardiographic parameters and prognosis in patients with DMS. The current study aimed to evaluate the prognostic value of left atrial volume index (LAVI) in patients with DMS.


A total of 155 patients with DMS (72[63-80] years, 67% female) were included. The population was divided according to LAVI: normal-sized LAVI (LAVI <= 34 ml/m2); and enlarged LAVI (> 34 ml/m2).


Patients with enlarged LAVI had a higher left ventricular mass index (120[96-146] vs. 91[70-112] g/m2 p < 0.001), as well as a higher prevalence of significant mitral regurgitation and severe aortic stenosis (23% vs. 10% p = 0.046 and 38% vs. 15% p=0.001, respectively) compared to patients with normal-sized LAVI. During a median follow-up of 25 months, 56 (36%) patients died. Patients with enlarged LAVI had worse prognosis compared to patients with normal-sized LAVI (p = 0.026). In multivariable Cox regression model, an enlarged LAVI was independently associated with all-cause mortality (HR 2.009, 95% CI 1.040 to 3.880, P = 0.038).


An enlarged LAVI (> 34 ml/m2) is significantly associated with excess mortality in patients with DMS. After adjusting for potential confounders, an enlarged LAVI was the only parameter that remained independently associated with prognosis.

Ladattava julkaisu

This is an electronic reprint of the original article.
This reprint may differ from the original in pagination and typographic detail. Please cite the original version.

Last updated on 2022-12-08 at 12:31