Refereed journal article or data article (A1)

Prognostic Value of Increased Mitral Valve Gradient After Transcatheter Edge-to-Edge Repair for Primary Mitral Regurgitation




List of AuthorsYoon Sung-Han, Makar Moody, Kar SIBL, Chakravarty Tarun, Oakley Luke, Sekhon Navjot, Koseki Keita, Enta Yusuke, Nakamura Mamoo, Hamilton Michele, Patel Jignesh K., Singh Siddharth, Skaf Sabah, Siegel Robert J., Bax Jeroen J., Makkar Raj R.

PublisherElsevier

Publication year2022

JournalJACC: Cardiovascular Interventions

Journal name in sourceJACC. Cardiovascular interventions

Volume number15

Issue number9

Start page935

End page945

ISSN1876-7605

eISSN1876-7605

DOIhttp://dx.doi.org/10.1016/j.jcin.2022.01.281

URLhttps://doi.org/10.1016/j.jcin.2022.01.281


Abstract
Objectives

This study sought to evaluate the prognostic value of an increased mean mitral valve pressure gradient (MVG) in patients with primary mitral regurgitation (MR) after transcatheter edge-to-edge repair (TEER).

Background

Conflicting data exist regarding impact of increased mean MVG on outcomes after TEER.

Methods

This study included 419 patients with primary MR (mean age 80.6 ± 10.4 years; 40.6% female) who underwent TEER. Patients were divided into quartiles (Qs) based on discharge echocardiographic mean MVG. Primary outcome was the composite endpoint of all-cause mortality and heart failure hospitalization. Secondary outcomes included all-cause mortality and the secondary composite endpoint of all-cause mortality, heart failure hospitalization, and mitral valve reintervention.

Results

The median number of MitraClips used was 2 per patient. MR reduction ≤moderate was achieved in 407 (97.1%) patients. Mean MVG was 1.9 ± 0.3 mm Hg, 3.0 ± 0.1 mm Hg, 4.0 ± 0.1 mm Hg, and 6.0 ± 1.2 mm Hg in Q1, Q2, Q3, and Q4, respectively. There was no significant differences across quartiles in the primary outcome (15.4%, 19.6%, 22.0%, and 21.9% in Q1-Q4, respectively; P = 0.63), all-cause mortality (15.9% vs 18.6% vs 19.4% vs 17.1%, respectively; P = 0.91), and the secondary composite endpoint at 2 years (33.3% vs 29.5% vs 22.0% vs 31.6%, respectively; P = 0.37). After multivariate adjustment for baseline clinical and procedural variables, the mean MVG in Q4 compared with Q1 to Q3 was not independently associated with the primary outcome (HR: 1.22; 95% CI: 0.82-1.83; P = 0.33), all-cause mortality, and the secondary composite endpoint.

Conclusions

Increased mean MVG was not independently associated with adverse events after TEER in patients with primary MR.


Last updated on 2023-15-06 at 16:13