A2 Refereed review article in a scientific journal
Segment-specific regulation of epididymal gene expression
Authors: Petra Sipilä, Ida Björkgren
Publisher: BIOSCIENTIFICA LTD
Publication year: 2016
Journal: Reproduction
Journal name in source: REPRODUCTION
Journal acronym: REPRODUCTION
Volume: 152
Issue: 3
First page : R91
Last page: R99
Number of pages: 9
ISSN: 1470-1626
DOI: https://doi.org/10.1530/REP-15-0533
Abstract
The epididymis is necessary for post-testicular sperm maturation. During their epididymal transit, spermatozoa gain ability for progressive movement and fertilization. The epididymis is composed of several segments that have distinct gene expression profiles that enable the establishment of the changing luminal environment required for sperm maturation. The epididymal gene expression is regulated by endocrine, lumicrine, and paracrine factors in a segment-specific manner. Thus, in addition to its importance for male fertility, the epididymis is a valuable model tissue for studying the regulation of gene expression. This review concentrates on recent advances in understanding the androgen, small RNA, and epigenetically mediated regulation of segment-specific gene expression in the epididymis.
The epididymis is necessary for post-testicular sperm maturation. During their epididymal transit, spermatozoa gain ability for progressive movement and fertilization. The epididymis is composed of several segments that have distinct gene expression profiles that enable the establishment of the changing luminal environment required for sperm maturation. The epididymal gene expression is regulated by endocrine, lumicrine, and paracrine factors in a segment-specific manner. Thus, in addition to its importance for male fertility, the epididymis is a valuable model tissue for studying the regulation of gene expression. This review concentrates on recent advances in understanding the androgen, small RNA, and epigenetically mediated regulation of segment-specific gene expression in the epididymis.
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