Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1)

Vaccine-Induced Antibody Responses against SARS-CoV-2 Variants-Of-Concern Six Months after the BNT162b2 COVID-19 mRNA Vaccination




Julkaisun tekijät: Jalkanen P., Kolehmainen P., Haveri A., Huttunen M., Laine L., Österlund P., Tähtinen P.A., Ivaska L., Maljanen S., Reinholm A., Belik M., Smura T., Häkkinen H.K., Ortamo E., Kantele A., Julkunen I., Lempainen J., Kakkola L.

Kustantaja: American Society for Microbiology

Julkaisuvuosi: 2022

Journal: Microbiology spectrum

Tietokannassa oleva lehden nimi: Microbiology Spectrum

Volyymi: 10

Julkaisunumero: 2

DOI: http://dx.doi.org/10.1128/spectrum.02252-21

Verkko-osoite: https://journals.asm.org/doi/10.1128/spectrum.02252-21

Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/175539192


Tiivistelmä

The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants has raised concern about increased transmissibility, infectivity, and immune evasion from a vaccine and infection-induced immune responses. Although COVID-19 mRNA vaccines have proven to be highly effective against severe COVID-19 disease, the decrease in vaccine efficacy against emerged Beta and Delta variants emphasizes the need for constant monitoring of new virus lineages and studies on the persistence of vaccine-induced neutralizing antibodies. To analyze the dynamics of COVID-19 mRNA vaccine-induced antibody responses, we followed 52 health care workers in Finland for 6 months after receiving two doses of BNT162b2 vaccine with a 3-week interval. We demonstrate that, although anti-S1 antibody levels decrease 2.3-fold compared to peak antibody levels, anti-SARS-CoV-2 antibodies persist for months after BNT162b2 vaccination. Variants D614G, Alpha, and Eta are neutralized by sera of 100% of vaccinees, whereas neutralization of Delta is 3.8-fold reduced and neutralization of Beta is 5.8-fold reduced compared to D614G. Despite this reduction, 85% of sera collected 6 months postvaccination neutralizes Delta variant.


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Last updated on 2022-06-07 at 13:07