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Vimentin Suppresses Inflammation and Tumorigenesis in the Mouse Intestine




Julkaisun tekijät: Wang Linglu, Mohanasundaram Ponnuswamy, Lindström Michelle, Asghar Muhammad Naheem, Sultana Giulia, Misiorek Julia O., Jiu Yaming, Chen Hongbo, Chen Zhi, Toivola Diana M., Cheng Fang, Eriksson John E.

Kustantaja: FRONTIERS MEDIA SA

Julkaisuvuosi: 2022

Journal: Frontiers in cell and developmental biology

Tietokannassa oleva lehden nimi: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY

Lehden akronyymi: FRONT CELL DEV BIOL

Volyymi: 10

Sivujen määrä: 13

ISSN: 2296-634X

eISSN: 2296-634X

DOI: http://dx.doi.org/10.3389/fcell.2022.862237

Verkko-osoite: https://doi.org/10.3389/fcell.2022.862237

Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/175279725


Tiivistelmä
Vimentin has been implicated in wound healing, inflammation, and cancer, but its functional contribution to intestinal diseases is poorly understood. To study how vimentin is involved during tissue injury and repair of simple epithelium, we induced colonic epithelial cell damage in the vimentin null (Vim(-/-)) mouse model. Vim(-/-) mice challenged with dextran sodium sulfate (DSS) had worse colitis manifestations than wild-type (WT) mice. Vim(-/-) colons also produced more reactive oxygen and nitrogen species, possibly contributing to the pathogenesis of gut inflammation and tumorigenesis than in WT mice. We subsequently describe that CD11b(+) macrophages served as the mainly cellular source of reactive oxygen species (ROS) production via vimentin-ROS-pSTAT3-interleukin-6 inflammatory pathways. Further, we demonstrated that Vim(-/-) mice did not develop colitis-associated cancer model upon DSS treatment spontaneously but increased tumor numbers and size in the distal colon in the azoxymethane/DSS model comparing with WT mice. Thus, vimentin has a crucial role in protection from colitis induction and tumorigenesis of the colon.

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Last updated on 2022-08-08 at 14:24