Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1)
Mood and neurotic disorders among youth with prenatal substance exposure: A longitudinal register-based cohort study
Julkaisun tekijät: Nissinen Niina-Maria, Sarkola Taisto, Autti-Rämö Ilona, Gissler Mika, Kahila Hanna, Koponen Anne M
Kustantaja: Elsevier
Julkaisuvuosi: 2022
Journal: Journal of Affective Disorders
Tietokannassa oleva lehden nimi: Journal of affective disorders
Lehden akronyymi: J Affect Disord
Volyymi: 308
Aloitussivu: 328
Lopetussivun numero: 336
ISSN: 0165-0327
eISSN: 1573-2517
DOI: http://dx.doi.org/10.1016/j.jad.2022.04.039
Verkko-osoite: https://doi.org/10.1016/j.jad.2022.04.039
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/175190027
BACKGROUND
Prenatal substance exposure is associated with mood and neurotic disorders but this association is complex and understudied. This study investigated the recorded use of specialised healthcare services for mood and neurotic disorders among youth with prenatal substance exposure in comparison with an unexposed matched cohort. Furthermore, the influence of adverse maternal characteristics and out-of-home care (OHC) is investigated.
METHODS
This longitudinal register-based matched cohort study included 594 exposed and 1735 unexposed youth. Cox proportional hazard regression models were applied to study the first episode of mood and neurotic disorders in specialised healthcare from 13 years of age, and the influence of adverse maternal characteristics and OHC. Mediation analysis was applied to study the mediating effect of OHC on the association between prenatal substance exposure and the disorders.
RESULTS
The exposed cohort had a two-fold higher likelihood of being treated at specialised healthcare for mood and neurotic disorders compared with the unexposed cohort (HR 2.34, 95% CI 1.86-2.95), but this difference was attenuated to non-significant levels (AHR 1.29, 95% CI 0.92-1.81) following adjustments with adverse maternal characteristics and OHC. OHC mediated 61% (95% CI 0.41-0.94) of the association between prenatal substance exposure and youth's mood and neurotic disorders.
LIMITATIONS
Register data likely include more severe cases of disorders, and as an observational study, causality cannot be assessed.
CONCLUSION
Mood and neurotic disorders are more common following prenatal exposure to substances and interlinked with significant adversities in the postnatal caregiving environment and OHC.
Ladattava julkaisu This is an electronic reprint of the original article. |