Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1)

Mood and neurotic disorders among youth with prenatal substance exposure: A longitudinal register-based cohort study




Julkaisun tekijätNissinen Niina-Maria, Sarkola Taisto, Autti-Rämö Ilona, Gissler Mika, Kahila Hanna, Koponen Anne M

KustantajaElsevier

Julkaisuvuosi2022

JournalJournal of Affective Disorders

Tietokannassa oleva lehden nimiJournal of affective disorders

Lehden akronyymiJ Affect Disord

Volyymi308

Aloitussivu328

Lopetussivun numero336

ISSN0165-0327

eISSN1573-2517

DOIhttp://dx.doi.org/10.1016/j.jad.2022.04.039

Verkko-osoitehttps://doi.org/10.1016/j.jad.2022.04.039

Rinnakkaistallenteen osoitehttps://research.utu.fi/converis/portal/detail/Publication/175190027


Tiivistelmä

BACKGROUND

Prenatal substance exposure is associated with mood and neurotic disorders but this association is complex and understudied. This study investigated the recorded use of specialised healthcare services for mood and neurotic disorders among youth with prenatal substance exposure in comparison with an unexposed matched cohort. Furthermore, the influence of adverse maternal characteristics and out-of-home care (OHC) is investigated.

METHODS

This longitudinal register-based matched cohort study included 594 exposed and 1735 unexposed youth. Cox proportional hazard regression models were applied to study the first episode of mood and neurotic disorders in specialised healthcare from 13 years of age, and the influence of adverse maternal characteristics and OHC. Mediation analysis was applied to study the mediating effect of OHC on the association between prenatal substance exposure and the disorders.

RESULTS

The exposed cohort had a two-fold higher likelihood of being treated at specialised healthcare for mood and neurotic disorders compared with the unexposed cohort (HR 2.34, 95% CI 1.86-2.95), but this difference was attenuated to non-significant levels (AHR 1.29, 95% CI 0.92-1.81) following adjustments with adverse maternal characteristics and OHC. OHC mediated 61% (95% CI 0.41-0.94) of the association between prenatal substance exposure and youth's mood and neurotic disorders.

LIMITATIONS

Register data likely include more severe cases of disorders, and as an observational study, causality cannot be assessed.

CONCLUSION

Mood and neurotic disorders are more common following prenatal exposure to substances and interlinked with significant adversities in the postnatal caregiving environment and OHC.


Ladattava julkaisu

This is an electronic reprint of the original article.
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Last updated on 2023-15-06 at 16:11