Refereed journal article or data article (A1)

Electrolyte profiles with induced hypothermia: A sub study of a clinical trial evaluating the duration of hypothermia after cardiac arrest




List of AuthorsKirkegaard Hans, Grejs Anders M., Gudbjerg Simon, Duez Christophe, Jeppesen Anni, Hassager Christian, Laitio Timo, Storm Christian, Taccone Fabio Silvio, Skrifvars Markus B., Søreide Eldar

PublisherWiley

Publication year2022

JournalActa Anaesthesiologica Scandinavica

Journal name in sourceACTA ANAESTHESIOLOGICA SCANDINAVICA

Journal acronymACTA ANAESTH SCAND

Volume number66

Issue number5

Start page615

End page624

Number of pages10

ISSN0001-5172

eISSN1399-6576

DOIhttp://dx.doi.org/10.1111/aas.14053

URLhttps://doi.org/10.1111/aas.14053

Self-archived copy’s web addresshttps://research.utu.fi/converis/portal/detail/Publication/174993116


Abstract

Background: Electrolyte disturbances can result from targeted temperature treatment (TTM) in out-of-hospital cardiac arrest (OHCA) patients. This study explores electrolyte changes in blood and urine in OHCA patients treated with TTM.

Methods: This is a sub-study of the TTH48 trial, with the inclusion of 310 unconscious OHCA patients treated with TTM at 33°C for 24 or 48 h. Over a three-day period, serum concentrations were obtained on sodium potassium, chloride, ionized calcium, magnesium and phosphate, as were results from a 24-h diuresis and urine electrolyte concentration and excretion. Changes over time were analysed with a mixed-model multivariate analysis of variance with repeated measurements.

Results: On admission, mean ± SD sodium concentration was 138 ± 3.5 mmol/l, which increased slightly but significantly (p < .05) during the first 24 h. Magnesium concentration stayed within the reference interval. Median ionized calcium concentration increased from 1.11 (IQR 1.1-1.2) mmol/l during the first 24 h (p < .05), whereas median phosphate concentration dropped to 1.02 (IQR 0.8-1.2) mmol/l (p < .05) and stayed low. During rewarming, potassium concentrations increased, and magnesium and ionizes calcium concentration decreased (p < .05). Median 24-h diuresis results on days one and two were 2198 and 2048 ml respectively, and the electrolyte excretion mostly stayed low in the reference interval.

Conclusions: Electrolytes mostly remained within the reference interval. A temporal change occurred in potassium, magnesium and calcium concentrations with TTM's different phases. No hypothermia effect on diuresis was detected, and urine excretion of electrolytes mostly stayed low.


Downloadable publication

This is an electronic reprint of the original article.
This reprint may differ from the original in pagination and typographic detail. Please cite the original version.




Last updated on 2023-12-05 at 10:37