A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Functional brown adipose tissue in healthy adults
Tekijät: Virtanen KA, Lidell ME, Orava J, Heglind M, Westergren R, Niemi T, Taittonen M, Laine J, Savisto NJ, Enerbäck S, Nuutila P
Julkaisuvuosi: 2009
Journal: New England Journal of Medicine
Tietokannassa oleva lehden nimi: The New England journal of medicine
Lehden akronyymi: N Engl J Med
Vuosikerta: 360
Numero: 15
Aloitussivu: 1518
Lopetussivu: 25
ISSN: 0028-4793
eISSN: 1533-4406
DOI: https://doi.org/10.1056/NEJMoa0808949
Tiivistelmä
Using positron-emission tomography (PET), we found that cold-induced glucose uptake was increased by a factor of 15 in paracervical and supraclavicular adipose tissue in five healthy subjects. We obtained biopsy specimens of this tissue from the first three consecutive subjects and documented messenger RNA (mRNA) and protein levels of the brown-adipocyte marker, uncoupling protein 1 (UCP1). Together with morphologic assessment, which showed numerous multilocular, intracellular lipid droplets, and with the results of biochemical analysis, these findings document the presence of substantial amounts of metabolically active brown adipose tissue in healthy adult humans.
Using positron-emission tomography (PET), we found that cold-induced glucose uptake was increased by a factor of 15 in paracervical and supraclavicular adipose tissue in five healthy subjects. We obtained biopsy specimens of this tissue from the first three consecutive subjects and documented messenger RNA (mRNA) and protein levels of the brown-adipocyte marker, uncoupling protein 1 (UCP1). Together with morphologic assessment, which showed numerous multilocular, intracellular lipid droplets, and with the results of biochemical analysis, these findings document the presence of substantial amounts of metabolically active brown adipose tissue in healthy adult humans.
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