A1 Refereed original research article in a scientific journal
Cerebral metabolic rate for glucose after neonatal hypoglycaemia
Authors: Kinnala A, Nuutila P, Ruotsalainen U, Teräs M, Bergman J, Haaparanta M, Solin O, Korvenranta H, Aärimaa T, Wegelius U, Kero P, Suhonen-Polvi H
Publication year: 1997
Journal: Early Human Development
Journal name in source: Early human development
Journal acronym: Early Hum Dev
Volume: 49
Issue: 1
First page : 63
Last page: 72
ISSN: 0378-3782
DOI: https://doi.org/10.1016/s0378-3782(97)01875-6
Abstract
OBJECTIVE\nMATERIALS AND METHODS\nRESULTS\nCONCLUSION\nWe studied the effect of neonatal hypoglycaemia on the local cerebral metabolic rate for glucose (LCMRglc).\nEight newborn infants with neonatal hypoglycaemia were studied. The LCMRglc in the whole brain, in five cerebral regions and in skeletal muscles were quantitated using positron emission tomography (PET) and 2-[18F]Fluoro-2-deoxy-D-glucose (FDG). The PET studies were performed at the age of 5.3 +/- 6.2 days during normoglycaemia. The LCMRglc of these infants were compared to the age-adjusted LCMRglc of eight infants with suspected hypoxic-ischaemic brain injury but with normal neurological development.\nAfter neonatal hypoglycaemia the age-adjusted LCMRglc in the whole brain was not lower than LCMRglc of the control infants (5.33 +/- 0.60 mumol/100 g/min vs. 6.71 +/- 0.60 mumol/100 g/min). Also the metabolic rate for glucose (MRglc) in the skeletal muscles was similar in hypoglycaemic and control infants (5.56 +/- 2.48 mumol/100 g/min vs. 6.99 +/- 2.41 mumol/100 g/min).\nMRglc in brain and in skeletal muscle seems to be normal after neonatal hypoglycaemia, although larger group of patients with more severe hypoglycaemia are needed to confirm this finding.
OBJECTIVE\nMATERIALS AND METHODS\nRESULTS\nCONCLUSION\nWe studied the effect of neonatal hypoglycaemia on the local cerebral metabolic rate for glucose (LCMRglc).\nEight newborn infants with neonatal hypoglycaemia were studied. The LCMRglc in the whole brain, in five cerebral regions and in skeletal muscles were quantitated using positron emission tomography (PET) and 2-[18F]Fluoro-2-deoxy-D-glucose (FDG). The PET studies were performed at the age of 5.3 +/- 6.2 days during normoglycaemia. The LCMRglc of these infants were compared to the age-adjusted LCMRglc of eight infants with suspected hypoxic-ischaemic brain injury but with normal neurological development.\nAfter neonatal hypoglycaemia the age-adjusted LCMRglc in the whole brain was not lower than LCMRglc of the control infants (5.33 +/- 0.60 mumol/100 g/min vs. 6.71 +/- 0.60 mumol/100 g/min). Also the metabolic rate for glucose (MRglc) in the skeletal muscles was similar in hypoglycaemic and control infants (5.56 +/- 2.48 mumol/100 g/min vs. 6.99 +/- 2.41 mumol/100 g/min).\nMRglc in brain and in skeletal muscle seems to be normal after neonatal hypoglycaemia, although larger group of patients with more severe hypoglycaemia are needed to confirm this finding.
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