Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1)

Oxytocin receptor genotype moderates the association between maternal prenatal stress and infant early self-regulation

Julkaisun tekijät: Kajanoja Jani, Nolvi Saara, Kantojärvi Katri , Karlsson Linnea, Paunio Tiina, Karlsson Hasse

Kustantaja: Elsevier

Julkaisuvuosi: 2022

Journal: Psychoneuroendocrinology

Tietokannassa oleva lehden nimi: Psychoneuroendocrinology

Lehden akronyymi: Psychoneuroendocrinology

Volyymi: 138

ISSN: 0306-4530

eISSN: 1873-3360



Rinnakkaistallenteen osoite:



Maternal prenatal stress may have long-term adverse consequences for child development. Accumulating evidence shows that the oxytocin-receptor genotype may play a role in differential susceptibility to early-life adversity, but no studies have examined whether this moderation extends to the prenatal stress exposures.


In the FinnBrain Birth Cohort Study, a sample of 1173 mother-child dyads were examined. We studied the possible moderating effect of the cumulative effect of infant oxytocin-receptor risk genotypes (rs53576GG and rs2254298A) in the association between maternal prenatal stress, and infant negative reactivity and emerging self-regulation at 6 months of age.


The number of OTr risk genotypes moderated the association between maternal prenatal anxiety and infant self-regulation, implying a cumulative effect of genotype, although effects sizes were small. In infants with two risk genotypes, a negative association between prenatal anxiety and self-regulation was observed, whereas in infants with one or no risk genotypes, the association between maternal prenatal anxiety and temperament was non-significant.


Oxytocin-receptor genotype may moderate the association of maternal stress during pregnancy and child social-emotional development. Possible mechanisms for this moderation effect are discussed. Further studies with a more comprehensive polygenic approach are needed to confirm these results.

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Last updated on 2022-29-04 at 12:00